Longitudinal transcriptomic and genetic landscape of radiotherapy response in canine melanoma

Veterinary and Comparative Oncology
Diana GiannuzziLuca Aresu

Abstract

Canine malignant melanoma (MM) is a highly aggressive tumour with a low survival rate and represents an ideal spontaneous model for the human counterpart. Considerable progress has been recently obtained, but the therapeutic success for canine melanoma is still challenging. Little is known about the mechanisms beyond pathogenesis and melanoma development, and the molecular response to radiotherapy has never been explored before. A faster and deeper understanding of cancer mutational processes and developing mechanisms are now possible through next generation sequencing technologies. In this study, we matched whole exome and transcriptome sequencing in four dogs affected by MM at diagnosis and at disease progression to identify possible genetic mechanisms associated with therapy failure. According to previous studies, a genetic similarity between canine MM and its human counterpart was observed. Several somatic mutations were functionally related to MAPK, PI3K/AKT and p53 signalling pathways, but located in genes other than BRAF, RAS and KIT. At disease progression, several mutations were related to therapy effects. Natural killer cell-mediated cytotoxicity and several immune-system-related pathways resulted activated opening a ...Continue Reading

References

Jul 27, 2000·Seminars in Immunology·R E Langman, M Cohn
Apr 19, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Suzanne ShellyCheryl A London
Dec 13, 2005·Cancer Cell·Omar Kabbarah, Lynda Chin
Jul 7, 2007·Expert Opinion on Therapeutic Targets·Henry B KoonPhilip W Tucker
Feb 28, 2008·Current Opinion in Oncology·Leslie A FecherKeith T Flaherty
Jul 10, 2009·American Journal of Physiology. Cell Physiology·Sulochana DeviVijayasaradhi Setaluri
Mar 20, 2010·Nature Reviews. Cancer·Daniel A TennantEyal Gottlieb
Aug 19, 2011·Veterinary and Comparative Oncology·A MurakamiK Maruo
May 25, 2012·Nature·Michael F BergerLevi A Garraway
May 25, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Abigail L ShearinElaine A Ostrander
Sep 1, 2012·World Journal of Biological Chemistry·Feng Zhang, Guangwei Du
Feb 12, 2013·Nature Biotechnology·Kristian CibulskisGad Getz
Feb 27, 2013·Lasers in Surgery and Medicine·Vivian T LaquerKristen M Kelly
Jun 12, 2013·Veterinary and Comparative Oncology·J S FowlesD L Gustafson
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Oct 1, 2013·American Journal of Human Genetics·Robert PiskolJin Billy Li
Oct 12, 2013·Pigment Cell & Melanoma Research·Marc GillardCatherine André
Oct 17, 2013·Pigment Cell & Melanoma Research·R Mark SimpsonStephen M Hewitt
Jun 11, 2014·Pigment Cell & Melanoma Research·Simon J FurneyRichard Marais
Dec 17, 2014·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Kelsey PoormanMatthew Breen
Jan 2, 2015·Current Protocols in Bioinformatics·Daniel C KoboldtRichard K Wilson
Dec 4, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kyle RettererSherri Bale
May 25, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jacquelyn M EvansLeigh Anne Clark
Jul 12, 2016·Canine Genetics and Epidemiology·Regina KropatschGabriele Dekomien
Mar 18, 2017·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Elisabete MacielM Rosário Domingues
May 4, 2017·Nature·Nicholas K HaywardGraham J Mann
Jul 3, 2017·Journal of Translational Medicine·Valeria RolihFederica Riccardo
Dec 30, 2017·Oncotarget·Anna PassarelliFrancesco Silvestris
May 8, 2018·NPJ Genomic Medicine·Guan-Yi LyuYu-Chao Wang

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Citations

Sep 11, 2019·Veterinary and Comparative Oncology·Clarissa ZamboniMassimo Castagnaro
Aug 29, 2019·Veterinary and Comparative Oncology·Anais ProuteauBenoît Hédan
Dec 4, 2019·Frontiers in Oncology·Kendall L LangstenJaime F Modiano
Dec 17, 2020·Animals : an Open Access Journal From MDPI·Ginevra BroccaMassimo Castagnaro
Mar 12, 2021·Advanced Drug Delivery Reviews·Lisa A Mestrinho, Ricardo R Santos

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