Longitudinal virological outcomes and factors associated with virological failure in behaviorally HIV-infected young adults on combination antiretroviral treatment in the Netherlands, 2000 to 2015

Medicine
A M WeijsenfeldATHENA observational HIV cohort

Abstract

Achieving and maintaining viral suppression in young adults (18-24 years) living with HIV is challenging. Overall HIV viral suppression rates are lower in young as compared to older adults. Longitudinal data provide valuable insight on dynamics of viral suppression and variables of potential influence on HIV virological failure (VF), but is scarce in young adults living with HIV on combination antiretroviral therapy (cART). We evaluated longitudinal virological outcomes of behaviorally young adults (18-24 years) living with HIV in the Netherlands over a period of 15 years.We analyzed data from the Dutch national HIV database of 816 young adults living with HIV on cART in the Netherlands from 2000 to 2015. VF was defined as 2 consecutive detectable plasma HIV-1 viral load (VL) measurements > 200 copies/ml. Generalized linear mixed model analyses were used to assess HIV VF over time and identify risk factors associated with VF.VF during the study follow-up occurred at least once in 26% of cases. The probability of experiencing VF decreased over the study period per calendar year (OR 0.78, 95% confidence interval [CI];0.72; 0.85). Factors significantly associated with VF were being infected through heterosexual contact (OR 5.20, C...Continue Reading

References

May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Aug 3, 2005·Archives of Pediatrics & Adolescent Medicine·Debra A MurphyUNKNOWN Adolescent Medicine HIV/AIDS Research Network
Aug 10, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Patrick RyscavageBabafemi Taiwo
Nov 2, 2011·AIDS and Behavior·Gary W HarperUNKNOWN Adolescent Medicine Trials Network for HIV/AIDS Interventions
Jul 16, 2013·SpringerPlus·Yiran Dong, Chao-Ying Joanne Peng
Mar 8, 2014·AIDS Patient Care and STDs·Brian C Zanoni, Kenneth H Mayer
Jan 7, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Baligh R YehiaUNKNOWN North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)
Feb 17, 2015·AIDS Patient Care and STDs·Sophia A HussenUNKNOWN Adolescent Medicine Trials Network for HIV/AIDS Interventions
Apr 2, 2016·PloS One·Shoshana Y KahanaUNKNOWN Adolescent Medicine Trials Network for HIV/AIDS Interventions
Oct 30, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Linda BeerUNKNOWN Medical Monitoring Project
Jul 13, 2016·JAMA : the Journal of the American Medical Association·Alison J RodgerUNKNOWN PARTNER Study Group
May 11, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Linda BeerUNKNOWN Medical Monitoring Project
Jul 26, 2017·HIV Medicine·UNKNOWN Migrant Health Working Group for the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroC
Sep 22, 2017·MMWR. Morbidity and Mortality Weekly Report·Sonia SinghBaohua Wu
Sep 27, 2018·BMJ Open·Tamara Sonia BoenderUNKNOWN ATHENA national observational HIV cohort

❮ Previous
Next ❯

Software Mentioned

SPSS SPSS Statistics
R Foundation for Statistical Computing
R

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.