Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins

International Journal of Obesity : Journal of the International Association for the Study of Obesity
J van DongenD I Boomsma

Abstract

Body mass index (BMI) discordant monozygotic (MZ) twins allow an examination of the causes and consequences of adiposity in a genetically controlled design. Few studies have examined longitudinal BMI discordance in MZ pairs. The aim of this work was to study the development over time of BMI discordance in adolescent and adult MZ twin pairs and to examine lifestyle, metabolic, inflammatory and gene expression differences associated with concurrent and long-term BMI discordance in MZ pairs. BMI data from 2775 MZ twin pairs, collected in eight longitudinal surveys and a biobank project between 1991 and 2011, were analyzed to characterize longitudinal discordance. Lifestyle characteristics were compared within discordant pairs (ΔBMI⩾3 kg m(-2)) and biomarkers (lipids, glucose, insulin, C-reactive protein, fibrinogen, interleukin (IL)-6, tumor necrosis factor-α and soluble IL-6 receptor and liver enzymes aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transferase) and gene expression were compared in peripheral blood from discordant pairs who participated in the Netherlands Twin Register biobank project. The prevalence of discordance ranged from 3.2% in 1991 (mean age=17, s.d.=2.4) to 17.4% (N=202 pairs) in 2...Continue Reading

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Citations

Apr 24, 2016·Obesity·Stieneke DoornweerdEco J de Geus
May 4, 2016·Mechanisms of Ageing and Development·Konstantin G ArbeevAnatoliy I Yashin
May 25, 2018·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Casey T FinnicumEco J C de Geus
Nov 2, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Lannie LigthartDorret I Boomsma
Jun 10, 2017·Brain Imaging and Behavior·Stieneke DoornweerdRichard G IJzerman

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Methods Mentioned

BETA
blood draw

Software Mentioned

GSEA
SPSS
MatSpD
R
GOrilla

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