Longstanding IgG4-related Ophthalmic Disease Dramatically Improved after Steroid Therapy

Internal Medicine
Yoko HirataYoshio Tsuboi

Abstract

A 61-year-old man was admitted to our hospital because of decreased visual acuity. On admission, he had marked blepharoedema, conjunctival injection, exophthalmos, diplopia, and blurred vision. He also had bronchial asthma and urinary retention requiring urethral catheterization. His serum immunoglobulin (Ig) G4 level was elevated to 1,830 U/mL. Fluorodeoxyglucose-positron emission tomography revealed an abnormal uptake in multiple organs. A histopathological examination of the salivary gland revealed IgG4-positive plasma cell infiltration, leading to a diagnosis of IgG4-related ophthalmic disease. After initiating steroid therapy, his longstanding ophthalmic, respiratory, and urinary symptoms dramatically improved. In IgG4-related disease, steroid therapy should be considered even if patients have longstanding symptoms.

References

Jun 2, 2011·Journal of Clinical and Experimental Hematopathology : JCEH·Yasufumi MasakiHisanori Umehara
Nov 3, 2011·The European Respiratory Journal·H YamamotoK Kubo
Feb 10, 2012·The New England Journal of Medicine·John H StoneVikram Deshpande
Aug 3, 2012·Japanese Journal of Ophthalmology·Yuka SogabeYasuharu Sato
Nov 14, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shoko MatsuiTakashi Ogura
Feb 27, 2013·JAMA Neurology·Ken OhyamaGen Sobue
Jan 5, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yuka SogabeTetsuya Nakamura
Feb 12, 2014·Seminars in Arthritis and Rheumatism·Zachary S WallaceJohn H Stone
Nov 14, 2014·Japanese Journal of Ophthalmology·Hiroshi GotoUNKNOWN Japanese Study Group for IgG4-Related Ophthalmic Disease
Jun 3, 2015·Journal of Ophthalmic Inflammation and Infection·Cecilia S LeeP Kumar Rao

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Masachika HayashiKazuhisa Mori
International Journal of Clinical and Experimental Pathology
Kentaro DoeYoshinari Takasaki
© 2022 Meta ULC. All rights reserved