Lonomia genus caterpillar envenomation: clinical and biological aspects

Haemostasis
C L Arocha-Piñango, B Guerrero

Abstract

Persons who have been in contact with Lonomia achelous or Lonomia obliqua caterpillars present external and internal bleeding and opening of recently healed wounds. Hematological tests show normal platelet count, prolonged prothrombin time, activated partial thromboplastin time and thrombin time, totally corrected by normal plasma. Decreased fibrinogen (Fg), factor (F) V, FXIII, plasminogen and alpha(2)-antiplasmin with increased FVIII: C, von Willebrand factor, Fg degradation products and D dimers. Tissue plasminogen activator, plasminogen activator inhibitor and protein C varied. In L. achelous biological fluids, compounds with anticoagulant or procoagulant properties have been identified. In L. obliqua bristle extracts, mainly procoagulant activities have been identified. Subcutaneous injections of L. achelous crude extracts and a semipurified fraction reduce Fg, plasminogen and FXIII in rabbits. Intravenous injections of a very purified fraction of L. achelous in rabbits produce lysis of preformed thrombi, a decrease of Fg, plasminogen, alpha(2)-antiplasmin, FXIII and inhibition of postthrombolytic thrombus growth. Subcutaneous injections of L. obliqua bristle extracts prolong prothrombin time and activated partial thrombop...Continue Reading

Citations

Mar 12, 2004·Thrombosis Research·Márcio FritzenAna Marisa Chudzinski-Tavassi
Dec 8, 2009·BMC Evolutionary Biology·Jeremy J Wright
Jul 16, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kris ChanLoree M Larratt
Aug 15, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sara LucenaCarmen L Arocha-Piñango
Feb 27, 2007·Toxicon : Official Journal of the International Society on Toxinology·Linda Christian Carrijo-Carvalho, Ana Marisa Chudzinski-Tavassi
Jan 22, 2005·Microscopy Research and Technique·Gustavo Henrique Da SilvaMaria Alice Da Cruz-Höfling
Aug 28, 2020·Frontiers in Pharmacology·Karla de Castro Figueiredo BordonEliane Candiani Arantes

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