Looking at Intergenerational Risk Factors in Schizophrenia Spectrum Disorders: New Frontiers for Early Vulnerability Identification?

Frontiers in Psychiatry
Michele PolettiAndrea Raballo

Abstract

Offspring of individuals with serious mental illness (SMI) constitute a special population with a higher risk of developing psychiatric disorders, which is also highly prevalent among referrals to child and adolescent mental health services (CAMHS). They often exhibit more or less subclinical conditions of vulnerability, fueled by mutually potentiating combinations of risk factors, such as presumed genetic risk, poor or inadequate affective and cognitive parenting, and low socio-economic status. Despite this evidence, neither specific preventive programs for offspring of parents with SMI are usually implemented in CAMHS, nor dedicated supportive programs for parenting are generally available in adult mental health services (AMHS). Needless to say, while both service systems tend to focus on individual recovery and clinical management (rather than on the whole family system), these blind spots add up to frequent gaps in communication and continuity of care between CAMHS and AMHS. This is particularly problematic in an age-range in which an offspring's vulnerabilities encounter the highest epidemiological peak of incident risk of SMI. This paper offers a clinical-conceptual perspective aimed to disentangle the complex intertwine ...Continue Reading

References

Oct 1, 1989·Archives of General Psychiatry·P E Meehl
Jan 1, 1987·Journal of Psychiatric Research·P TienariL C Wynne
Jan 1, 1987·Schizophrenia Bulletin·A SameroffR Barocas
Jan 1, 1996·Schizophrenia Bulletin·A R Yung, P D McGorry
Aug 23, 2000·The American Journal of Orthopsychiatry·D OysermanK B Firminger
Jul 2, 2002·The American Journal of Psychiatry·Mary CannonRobin M Murray
Mar 27, 2003·Comprehensive Psychiatry·Josef Parnas, Peter Handest
Oct 18, 2003·Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43)·Marilyn J KwongShanna J Trinke
Mar 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Pekka TienariKarl-Erik Wahlberg
Oct 12, 2004·Schizophrenia Research·Margriet M SitskoornRené S Kahn
Dec 31, 2004·The American Journal of Psychiatry·Elizabeth Cantor-Graae, Jean-Paul Selten
Sep 10, 2005·Schizophrenia Bulletin·Lydia Krabbendam, Jim van Os
Jul 27, 2006·The Australian and New Zealand Journal of Psychiatry·Patrick D McGorryHenry J Jackson
Sep 6, 2007·Genome Research·Naomi R WrayPeter M Visscher
Oct 7, 2008·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Patrick D McGorryAlison Yung
Feb 4, 2010·The American Journal of Psychiatry·Alan S Brown, Elena J Derkits
Jun 3, 2010·The American Journal of Psychiatry·John H GilmoreGuido Gerig
Dec 20, 2011·Journal of the American Academy of Child and Adolescent Psychiatry·Eliane SiegenthalerMatthias Egger
Jun 22, 2012·Psychological Medicine·S L MathesonV J Carr
Sep 28, 2012·Schizophrenia Bulletin·Evangelos VassosCathryn M Lewis
Nov 21, 2012·JAMA Psychiatry·Paolo Fusar-PoliAlison Yung
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H W ThermenosL J Seidman
May 1, 2015·Schizophrenia Bulletin·Larry J Seidman, Merete Nordentoft
Jul 15, 2015·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Patrick W CorriganDeborah A Perlick
Oct 12, 2015·Social Psychiatry and Psychiatric Epidemiology·Kirstine Agnete DavidsenAndrew Gumley
Mar 10, 2016·Harvard Review of Psychiatry·Mohajer Abbass Hameed, Andrew James Lewis
Mar 19, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Virginia A Rauh, Amy E Margolis
Jun 21, 2016·AMA Journal of Ethics·Dominic A Sisti, Monica E Calkins
Jun 24, 2016·NPJ Schizophrenia·Iris E SommerJacob As Vorstman
Jul 2, 2016·The American Journal of Psychiatry·Tyrone D CannonMichael W Kattan
Aug 31, 2016·Journal of Developmental Origins of Health and Disease·R J Van Lieshout, J E Krzeczkowski
Nov 15, 2016·The American Journal of Psychiatry·Kieran J O'Donnell, Michael J Meaney
Dec 20, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·P Fusar-PoliP McGuire

❮ Previous
Next ❯

Citations

Mar 4, 2021·Expert Review of Neurotherapeutics·Mary V Seeman
Nov 20, 2021·Journal of Clinical Psychology·Lorenzo PelizzaAndrea Raballo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.