Looking for immunological risk genotypes

Annals of the New York Academy of Sciences
Calogero CarusoDomenico Lio

Abstract

Several functional markers of the immune system may be used either as markers of successful aging or conversely as markers of unsuccessful aging. Particularly, a combination of high CD8 and low CD4 and poor T cell proliferation has been associated with a higher two-year mortality in very old subjects. Therefore, genetic determinants of longevity should reside in those polymorphisms for the immune system genes that regulate immune responses. Concerning these changes in T cell subpopulations, how much they depend on the immunogenetic background and how much they depend on individual antigenic load, such as chronic infections, should be assessed. As previously demonstrated in our population, the interleukin (IL)-2 high-producer genotype is less frequent in old men than in young people; conversely, the IL-10 high-producer genotype is increased in old men. In this study, we tried to assess the role of low- and high-producer genotypes for IL-10 and IL-2 in the CD4 and CD8 absolute values, taking into account gender and age. The results suggest that old men carrying an anti-inflammatory IL-10 high-producer genotype or a proinflammatory IL-2 low-producer genotype show the lowest values of CD8 cells. Although in our study we were not ab...Continue Reading

References

Oct 26, 1999·Experimental Gerontology·M PotestioG C Romano
Sep 21, 2000·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M P ReynardC V Navarrete
May 7, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Graham PawelecRafael Solana
Jul 10, 2002·Trends in Immunology·Graham PawelecCalogero Caruso

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Citations

Oct 4, 2012·Human Mutation·Gareth BaynamJack Goldblatt
Feb 1, 2012·Medical Hypotheses·G BaynamP Le Souef

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