Looking for novel, brain-derived, peripheral biomarkers of neurological disorders

Neurologia i neurochirurgia polska
Natalia ChmielewskaAdam Płaźnik

Abstract

The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, noninvasive and reliable method for monitoring of BBB condition. It seems that revealing the peripheral diagnostic biomarker whose release pattern (concentration, dynamics) will be correlated with clinical symptoms of neurological disorders offers significant hope. It could help with faster diagnosis and efficient treatment monitoring. In this review we summarize the recent data concerning exploration of potential new serum biomarkers appearing in the peripheral circulation following BBB disintegration, with an emphasis on epilepsy, traumatic brain injury (TBI) and stroke. We consider the application of well-known proteins (S100β and GFAP) as serum indicators in the light of recently obtained results. Furthermore, the utility of molecules like MMP-9, UCHL-1, neurofilaments, BDNF, and miRNA, which are newly recognized as a potential serum biomarkers, will also be discussed.

References

Mar 4, 2000·Cellular and Molecular Neurobiology·N J Abbott
Jul 4, 2001·Nature Reviews. Neuroscience·V W YongD R Edwards
Sep 23, 2003·Clinical Chemistry·Mark A ReynoldsKenneth F Buechler
Nov 3, 2004·Growth Factors·Devin K Binder, Helen E Scharfman
Sep 22, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·C FoerchM Sitzer
Jul 14, 2007·Pediatric Neurosurgery·O PiazzaR Tufano
Aug 2, 2007·Nature Reviews. Drug Discovery·Romeo CecchelliLaurence Fenart
Mar 6, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stephen B LewisGerry Shaw
Oct 14, 2008·The Journal of Trauma·Kimberly M LumpkinsThomas Scalea
Oct 25, 2008·Stroke; a Journal of Cerebral Circulation·Daniel T LaskowitzUNKNOWN BRAIN Study Group
Dec 27, 2008·Biochimica Et Biophysica Acta·Rosario DonatoIleana Giambanco
Feb 17, 2009·The Journal of Emergency Medicine·Simone VanniStefano Grifoni
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fahima MayerRoland J Bainton
Dec 10, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alexander T BauerHugo H Marti
Jul 2, 2010·Frontiers in Neuroscience·Alexandre HenriquesArmin Schneider
Nov 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Maria Ramos-FernandezLatha G Stead
Oct 12, 2011·The Journal of Trauma·Jiří Zurek, Michal Fedora
Nov 4, 2011·Nature Reviews. Neuroscience·Berislav V Zlokovic
Aug 7, 2012·Journal of the Neurological Sciences·Takeshi MatsushigeTakashi Ichiyama
Sep 8, 2012·Journal of Cell Science·Aidong YuanRalph A Nixon
Jan 12, 2013·Fluids and Barriers of the CNS·Arsalan S HaqqaniDanica B Stanimirovic
Jul 25, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Z HongD Zhou
Nov 5, 2013·Physiology·Andriy YabluchanskiyMerry L Lindsey
Feb 12, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Sandra AmorFabiola Puentes
May 13, 2014·Fluids and Barriers of the CNS·Thomas BrinkerPetra Klinge
Jul 16, 2014·Cancer Investigation·Ryan P LangeMatthias Holdhoff

❮ Previous
Next ❯

Citations

Nov 13, 2020·Science Translational Medicine·Tania F GendronLeonard Petrucelli
May 1, 2021·Pharmaceuticals·Jung Hak KimHong Jun Lee
Aug 8, 2021·Environmental Science and Pollution Research International·Hagar N Abd AllahEman S Abdel-Reheim
Aug 6, 2018·Seizure : the Journal of the British Epilepsy Association·Leila SimaniMarjan Asadollahi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Z HongD Zhou
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
Ismet TopçuMelek Civi
The Journal of Head Trauma Rehabilitation
Asli Demirtas-TatlidedeAlvaro Pascual-Leone
© 2022 Meta ULC. All rights reserved