Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging biomarker of disease resistance, which may be related to several recently documented biological functions. Initially believed to be toxic in infants, the perception of bilirubin has undergone a transformation: it is now considered to be a molecule that may promote health in adults. Data from the last decade demonstrate that mildly elevated serum bilirubin levels are strongly associated with reduced prevalence of chronic diseases, particularly cardiovascular diseases (CVDs), as well as CVD-related mortality and risk factors. Recent data also link bilirubin to other chronic diseases, including cancer and Type 2 diabetes mellitus, and to all-cause mortality. Therefore, there is evidence to suggest that bilirubin is a biomarker for reduced chronic disease prevalence and a predictor of all-cause mortality, which is of important clinical significance. In the present review, detailed information on the association between bilirubin and all-cause mortality, as well as the pathological conditions of CVD, cancer, diabetes and neurodegenerative diseases, is provided. The mechanistic background concerning how bilirubin and its metabolism may influenc...Continue Reading
Surface activities of procaine, lidocaine, and tetracaine and their interaction energies with phospholipid monolayers
Antioxidant properties of conjugated bilirubin and biliverdin: biologically relevant scavenging of hypochlorous acid
Comparison between fractional turnover rate of endogenous plasma triglycerides and of intralipid (intravenous fat tolerance test) in man
Studies on hemoglobin Tochigi diseases ( 56-59 deleted) with particular reference to its osmotic fragility test by heating
Experimental databases on inhibition of the bacterial mutagenicity of 4-nitroquinoline 1-oxide and cigarette smoke
Binding of polycyclic planar mutagens to chlorophyllin resulting in inhibition of the mutagenic activity
Structural basis of antimutagenicity of chemicals towards 4-nitroquinoline 1-oxide in Salmonella typhimurium
Increased plasma bilirubin in Parkinson patients on L-dopa: evidence against the free radical hypothesis?
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury
Intestinal colonization leading to fecal urobilinoid excretion may play a role in the pathogenesis of neonatal jaundice
Comparison of various lipid, lipoprotein, and bilirubin combinations as risk factors for predicting coronary artery disease
Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance
Remnant-like particle (RLP) cholesterol is an independent cardiovascular disease risk factor in women: results from the Framingham Heart Study
Serum levels of micronutrients, antioxidants and total antioxidant status predict risk of breast cancer in a case control study
A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2)
Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies
Bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1) gene promoter polymorphisms and HPRT, glycophorin A, and micronuclei mutant frequencies in human blood
Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization
Pre- or post-ischemic bilirubin ditaurate treatment reduces oxidative tissue damage and improves cardiac function
Features of an altered AMPK metabolic pathway in Gilbert's Syndrome, and its role in metabolic health
Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial
Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα
Endogenously elevated bilirubin modulates kidney function and protects from circulating oxidative stress in a rat model of adenine-induced kidney failure
Evaluation of region selective bilirubin-induced brain damage as a basis for a pharmacological treatment
Hyperbilirubinemia in Gunn Rats is Associated with Decreased Inflammatory Response in LPS-Mediated Systemic Inflammation
Mildly decreased preoperative bilirubin levels are associated with infections after shoulder and knee arthroplasty
Serum Bilirubin in the Czech Population - Relationship to the Risk of Myocardial Infarction in Males.
Longer telomeres in chronic, moderate, unconjugated hyperbilirubinaemia: insights from a human study on Gilbert's Syndrome
Characteristics of the heme catabolic pathway in mild unconjugated hyperbilirubinemia and their associations with inflammation and disease prevention
Association between Hemoglobin Levels and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes: A Cross-Sectional Study Using Electronic Health Records
Serum Bilirubin Levels and Promoter Variations in HMOX1 and UGT1A1 Genes in Patients with Fabry Disease
Bilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea.
Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?
Association between serum bilirubin and asymptomatic intracranial atherosclerosis: results from a population-based study.
The Association between Serum Bilirubin Levels and Colorectal Cancer Risk: Results from the Prospective Cooperative Health Research in the Region of Augsburg (KORA) Study in Germany
Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.
Beyond a Measure of Liver Function-Bilirubin Acts as a Potential Cardiovascular Protector in Chronic Kidney Disease Patients
Bilirubin and Ischemic Stroke: Rendering the Current Paradigm to Better Understand the Protective Effects of Bilirubin
Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice
Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang.
Unconjugated Bilirubin Is a Novel Prognostic Biomarker for Nasopharyngeal Carcinoma and Inhibits Its Metastasis via Antioxidation Activity
Serum Total Bilirubin and Progression of Chronic Kidney Disease and Mortality: A Systematic Review and Meta-Analysis.
Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2.
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