Loops on loops: generation of complex scaffolded peptides presenting multiple cyclic fragments

Organic & Biomolecular Chemistry
Raimo FrankeJ Eichler

Abstract

Scaffolded peptides presenting two different cyclic peptide fragments through a cyclic peptidomimetic scaffold in a site-selective fashion, were generated by stepwise solid phase synthesis and fragment condensation in parallel, demonstrating that either strategy is adequate to generate complex scaffolded peptides.

Citations

Oct 22, 2008·Current Opinion in Chemical Biology·Jutta Eichler
Jul 23, 2015·Journal of Peptide Science : an Official Publication of the European Peptide Society·Uwe KafurkeJutta Eichler
Nov 23, 2006·Journal of Receptor and Signal Transduction Research·Raimo FrankeJutta Eichler
Dec 4, 2014·Chembiochem : a European Journal of Chemical Biology·Linde E J SmeenkPeter Timmerman
Jan 11, 2007·Angewandte Chemie·Raimo FrankeJutta Eichler
Sep 22, 2007·Chembiochem : a European Journal of Chemical Biology·Dirk-Jan van ZoelenRob M J Liskamp
Aug 8, 2006·Chembiochem : a European Journal of Chemical Biology·Yashveer SinghPascal Dumy

Related Concepts

High Pressure Liquid Chromatography Procedure
In Vivo NMR Spectroscopy
Peptide Fragments
Polypeptides
Cyclic Peptides
Biomimetic Materials

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.