PMID: 6437509Nov 10, 1984Paper

Loperamide in acute diarrhoea in childhood: results of a double blind, placebo controlled multicentre clinical trial. Diarrhoeal Diseases Study Group (UK)

British Medical Journal


A total of 315 young children with acute diarrhoea were included in a double blind, hospital based multicentre trial of loperamide at two dose levels (0.8 mg and 0.4 mg/kg/24 h), given with standard oral rehydration therapy versus placebo plus oral rehydration therapy. The overall recovery rate was slowest in the placebo group and fastest in the group given loperamide 0.8 mg. Comparisons between weights on admission and weights by day 3 showed that a larger proportion of children in the loperamide groups gained weight than in the placebo group. No serious side effects of loperamide were observed, but the drug was withdrawn in one infant because of mild abdominal distention. The results indicate that loperamide, in the doses employed, is safe and may in selected cases be a useful adjunct to oral rehydration in the management of acute diarrhoea in well nourished children.


Aug 5, 1978·Lancet
Mar 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R A KaplanC Y Pak
Jan 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·M Wüster, A Herz
Feb 1, 1979·Australian and New Zealand Journal of Medicine·S PosenR S Mason
Oct 1, 1976·The British Journal of Radiology·S K TheA Talerman
Jan 1, 1968·Acta Chemica Scandinavica·J Uitto, O Laitinen
Jun 1, 1981·The American Journal of Surgical Pathology·E J KasdonW Silen
Aug 1, 1981·Gut·B K SandhuJ T Harries
Nov 26, 1983·British Medical Journal·W Van'T HoffE J Bicknell
Apr 1, 1984·American Journal of Surgery·R D Gaz, C A Wang
Jan 1, 1982·Journal of Pediatric Gastroenterology and Nutrition·J WattJ T Harries
Jan 1, 1983·Archives of Disease in Childhood·B K SandhuJ T Harries
Jun 1, 1980·Antimicrobial Agents and Chemotherapy·F A Barada, R L Guerrant
Feb 1, 1982·Annals of Internal Medicine·J P Bilezikian
Aug 1, 1981·Journal of the American Geriatrics Society·M A FiataroneR H Egdahl
Sep 1, 1981·Journal of Gerontology·B M Lifschitz, U S Barzel
Jan 24, 1980·The New England Journal of Medicine·H HeathM A Kennedy
Jan 24, 1980·The New England Journal of Medicine·F L Coe, M J Favus
Feb 1, 1980·The British Journal of Surgery·J J GrahamP H Wise
Jun 14, 1980·British Medical Journal·D A HeathN J Dorricott
Aug 16, 1980·British Medical Journal·J C Stevenson, J Lynn
May 1, 1948·Cancer·W G CAHAN, H Q WOODARD


Jul 1, 1995·Indian Journal of Pediatrics·M B RaghuA Ramnath
Nov 1, 1991·Indian Journal of Pediatrics·M K Bhan, S Bhatnagar
Aug 1, 1994·Social Science & Medicine·P TouchetteL W Duke
Jun 1, 1990·Journal of the American College of Nutrition·F LifshitzH da C Ribeiro
May 20, 2008·Travel Medicine and Infectious Disease·William M StaufferPhilip R Fischer
Apr 1, 1991·The Journal of Pediatrics·L K Pickering
Feb 1, 1997·Emergency Medicine Clinics of North America·J A FosterL M Bell
Mar 1, 2003·Paediatric Drugs·Nure H Alam, Hasan Ashraf
Jul 1, 1992·Clinical Pediatrics·W R Treem
Dec 1, 1984·British Medical Journal·H G Easton
Dec 1, 1989·Postgraduate Medicine·A K Leung, W L Robson
Sep 1, 2003·Paediatrics & Child Health
Jun 29, 2002·Journal of Travel Medicine·William M StaufferDeepak Kamat
Aug 1, 1995·Alimentary Pharmacology & Therapeutics·J W Dreverman, A J Van der Poel

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