PMID: 6830273Jan 1, 1983

Loperamide in severe protracted diarrhoea

Archives of Disease in Childhood
B K SandhuJ T Harries

Abstract

Six infants with severe life-threatening protracted diarrhoea were treated with loperamide. Steady-state perfusion studies of the jejunum showed that in 2 of them the small intestine was in a net secretory state with respect to water, and in the others this was inferred from the fact that the diarrhoea persisted despite nothing by mouth. Loperamide resulted in a prompt and impressive improvement in the condition of each infant. We conclude that this drug has an important role in the management of protracted diarrhoeal states in some infants who are unresponsive to current treatments, and that its effect is related to its antisecretory action.

References

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Mar 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·E Beubler, F Lembeck
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Jan 1, 1981·Archives of Disease in Childhood·D C CandyJ T Harries

Citations

Apr 1, 1989·European Journal of Pediatrics·P DemolT R Weihrauch
Sep 1, 1985·Indian Journal of Pediatrics·M K BhanO P Ghai
Jan 1, 1984·Indian Journal of Pediatrics·B K Sandhu, P J Milla
Jul 1, 1983·Archives of Disease in Childhood·L T WeaverR Nelson
Mar 1, 1984·Archives of Disease in Childhood·P I Macfarlane, V Miller
Nov 10, 1984·British Medical Journal·D C Candy
Oct 1, 1985·Postgraduate Medical Journal·D Barltrop, B K Sandhu
Apr 14, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Mohammed A AlShahwanFahad M AlSaif
Jul 28, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Horst KochErwin Scharnagl
Apr 23, 2014·Journal of Labelled Compounds & Radiopharmaceuticals·Crist N FilerRichard P Nugent

Related Concepts

Infantile Diarrhea
Jejunum
Imodium
Perfusion
Piperidines

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