PMID: 6272133Sep 1, 1981

Loperamide reduces the intestinal secretion but not the mucosal cAMP accumulation induced by choleratoxin

Naunyn-Schmiedeberg's Archives of Pharmacology
U M FarackK Loeschke


The effect of loperamide on net fluid transport and epithelial cAMP accumulation was tested in choleratoxin-exposed ligated colon loops of the rat in vivo. Purified choleratoxin (50 micrograms/ml saline, for 5 h) induced net secretion and doubled cAMP levels in comparison with saline-treated controls. Loperamide (4 mg/kg intragastrically) reduced this secretion by 75%, without diminishing cAMP accumulation; it had no effect on basal fluid transport or cAMP. The data suggest that the opiate analogue interferes with the secretory process at a point beyond the cAMP increase caused by activation of adenylate cyclase.


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Jun 1, 1971·The Journal of Clinical Investigation·D V KimbergE Gershon
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D E SchaferN D Goldberg
Apr 1, 1974·Analytical Biochemistry·C O Brostrom, C Kon
Oct 1, 1980·The Journal of Clinical Investigation·K DharmsathaphornJ Dobbins


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Mar 1, 1984·Digestive Diseases and Sciences·I Altaparmakov, M Wienbeck
Feb 1, 1992·Digestive Diseases and Sciences·G StacherG Stacher-Janotta
Sep 1, 1986·Veterinary Research Communications·L Ooms, A Degryse
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Jul 1, 1996·The Journal of Pharmacy and Pharmacology·M V DiurnoF Capasso
Feb 1, 1994·Gut·D R Nalin
Jan 1, 1987·The Journal of Membrane Biology·D D MaenzG W Forsyth
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·T Hedner, J Cassuto
Apr 1, 1983·The Journal of Pharmacy and Pharmacology·M K Lee, I M Coupar
Mar 19, 2014·Pharmaceutical Biology·Gabriel A AgborProtus Arrey Tarkang
Jul 27, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A WasilewskiJ Fichna
May 19, 2000·The Proceedings of the Nutrition Society·A HeerschapB Wieringa
Jun 1, 1993·Digestive Diseases and Sciences·F AwoutersP A Janssen
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