PMID: 6272133Sep 1, 1981

Loperamide reduces the intestinal secretion but not the mucosal cAMP accumulation induced by choleratoxin

Naunyn-Schmiedeberg's Archives of Pharmacology
U M FarackK Loeschke

Abstract

The effect of loperamide on net fluid transport and epithelial cAMP accumulation was tested in choleratoxin-exposed ligated colon loops of the rat in vivo. Purified choleratoxin (50 micrograms/ml saline, for 5 h) induced net secretion and doubled cAMP levels in comparison with saline-treated controls. Loperamide (4 mg/kg intragastrically) reduced this secretion by 75%, without diminishing cAMP accumulation; it had no effect on basal fluid transport or cAMP. The data suggest that the opiate analogue interferes with the secretory process at a point beyond the cAMP increase caused by activation of adenylate cyclase.

References

Mar 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·E Beubler, F Lembeck
Feb 1, 1977·Prostaglandins·S M Karim, P G Adaikan
Jan 22, 1971·Nature·G W Sharp, S Hynie
Jun 1, 1971·The Journal of Clinical Investigation·D V KimbergE Gershon
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D E SchaferN D Goldberg
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Citations

Aug 17, 2001·Phytotherapy Research : PTR·A L AbdullahiC Wambebe
Mar 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·U M Farack, K Loeschke
Feb 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·T NakakiR Kato
Mar 1, 1984·Digestive Diseases and Sciences·I Altaparmakov, M Wienbeck
Feb 1, 1992·Digestive Diseases and Sciences·G StacherG Stacher-Janotta
Sep 1, 1986·Veterinary Research Communications·L Ooms, A Degryse
May 24, 2005·Journal of Ethnopharmacology·Abdulkarim AgunuEzzeldin Mukhtar Abdurahman
Jul 1, 1996·The Journal of Pharmacy and Pharmacology·M V DiurnoF Capasso
Feb 1, 1994·Gut·D R Nalin
Jan 1, 1987·The Journal of Membrane Biology·D D MaenzG W Forsyth
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·T Hedner, J Cassuto
Apr 1, 1983·The Journal of Pharmacy and Pharmacology·M K Lee, I M Coupar
Mar 19, 2014·Pharmaceutical Biology·Gabriel A AgborProtus Arrey Tarkang
Jul 27, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A WasilewskiJ Fichna
May 19, 2000·The Proceedings of the Nutrition Society·A HeerschapB Wieringa
Jun 1, 1993·Digestive Diseases and Sciences·F AwoutersP A Janssen
Jun 1, 1987·Alimentary Pharmacology & Therapeutics·H Ruppin

Related Concepts

Cyclic AMP, (R)-Isomer
Procholeragenoid
Structure of Intestinal Gland
Imodium
Piperidines
August Rats

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