PMID: 8599188Oct 1, 1995Paper

Lophozozymus pictor toxin: a fluorescent structural isomer of palytoxin

Toxicon : Official Journal of the International Society on Toxinology
C O LauG S Bignami

Abstract

Purified Lophozozymus pictor toxin (LPTX) shares many properties similar to palytoxin (PTX). LPTX and palytoxin isolated from Palythoa caribaeorum (C-PTX) have similar mol. wts of approx. 2680 on ionspray mass spectrometry (MS). In addition, antibodies against PTX could recognize and bind LPTX. Mixed mode high-performance liquid chromatography (HPLC) of LPTX, C-PTX and H-PTX (isolated from Palythoa tuberculosa) showed a major PTX component common to all three with the characteristic PTX-like UV spectrum at a retention time (Rt) of 17 min. However, LPTX exhibits fluorescence but PTX of equivalent toxicity does not. LPTX showed a unique peak at Rt of approx. 22 min on mixed mode HPLC. In addition, LPTX and C-PTX showed different ion fragmentation patterns on MS/MS. These results suggest that LPTX and the palytoxins are structural isomers, containing at least one difference which gives rise to fluorescence in LPTX.

References

Jan 1, 1977·Toxicon : Official Journal of the International Society on Toxinology·R B Gonzales, A C Alcala
Jul 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·G S BignamiD C Vann
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·L LevineH Van Vunakis
Dec 1, 1974·Toxicon : Official Journal of the International Society on Toxinology·Y F Teh, J E Gardiner
Jan 1, 1983·Toxicon : Official Journal of the International Society on Toxinology·L BéressO Wassermann
Oct 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·C O LauC H Tan
Jun 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·G S Bignami
Jul 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·D G ChiaC H Tan
Jul 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·C O LauH E Khoo

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Citations

Jan 25, 2011·Toxicon : Official Journal of the International Society on Toxinology·A TubaroS Sosa
Dec 4, 2010·Toxicon : Official Journal of the International Society on Toxinology·Katerina AligizakiJorge Diogène
Oct 12, 2010·Toxicon : Official Journal of the International Society on Toxinology·Pilar Riobó, José M Franco
Jun 10, 2009·Toxicon : Official Journal of the International Society on Toxinology·Jonathan R Deeds, Michael D Schwartz
Mar 10, 2009·Toxicon : Official Journal of the International Society on Toxinology·Chau H Wu
Mar 1, 2012·Analytical Biochemistry·A AlfonsoL M Botana

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