Abstract
The efficacies of lopinavir-ritonavir or hydroxychloroquine remain to be determined in patients with coronavirus disease 2019 (COVID-19). To compare the virological and clinical responses to lopinavir-ritonavir and hydroxychloroquine treatment in COVID-19 patients. This retrospective cohort study included patients with COVID-19 treated with lopinavir-ritonavir or hydroxychloroquine at a single center in Korea from February 17 to March 31, 2020. Patients treated with lopinavir-ritonavir and hydroxychloroquine concurrently and those treated with lopinavir-ritonavir or hydroxychloroquine for less than 7 days were excluded. Time to negative conversion of viral RNA, time to clinical improvement, and safety outcomes were assessed after 6 weeks of follow-up. Of 65 patients (mean age, 64.3 years; 25 men [38.5%]), 31 were treated with lopinavir-ritonavir and 34 were treated with hydroxychloroquine. The median duration of symptoms before treatment was 7 days and 26 patients (40%) required oxygen support at baseline. Patients treated with lopinavir-ritonavir had a significantly shorter time to negative conversion of viral RNA than those treated with hydroxychloroquine (median, 21 days vs. 28 days). Treatment with lopinavir-ritonavir (adju...Continue Reading
References
May 15, 2003·Science·Kanchan AnandRolf Hilgenfeld
Nov 1, 2003·The Lancet Infectious Diseases·Andrea SavarinoRoberto Cauda
Feb 27, 2004·Thorax·C M ChuUNKNOWN HKU/UCH SARS Study Group
Aug 4, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·F ChenK Y Yuen
Sep 8, 2004·Biochemical and Biophysical Research Communications·Els KeyaertsMarc Van Ranst
Sep 11, 2004·Biochemical and Biophysical Research Communications·Rajendram V RajnarayananNagarajan Pattabiraman
Aug 24, 2005·Virology Journal·Martin J VincentStuart T Nichol
Apr 28, 2006·Journal of Medicinal Chemistry·Christophe BiotErik De Clercq
Jan 30, 2008·Cell Research·Hongliang WangChengyu Jiang
May 21, 2014·Antimicrobial Agents and Chemotherapy·Adriaan H de WildeEric J Snijder
Feb 3, 2020·Lancet·Nanshan ChenLi Zhang
Feb 6, 2020·Cell Research·Manli WangGengfu Xiao
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 15, 2020·Journal of Korean Medical Science·Jaegyun LimSang Joon Park
Mar 4, 2020·JAMA : the Journal of the American Medical Association·Barnaby Edward YoungUNKNOWN Singapore 2019 Novel Coronavirus Outbreak Research Team
Mar 5, 2020·Nature Reviews. Drug Discovery·Guangdi Li, Erik De Clercq
Mar 7, 2020·Cell·Markus HoffmannStefan Pöhlmann
Mar 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xueting YaoDongyang Liu
Mar 15, 2020·Lancet·Fei ZhouBin Cao
Mar 17, 2020·International Journal of Antimicrobial Agents·Christian A DevauxDidier Raoult
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang
Mar 25, 2020·International Journal of Antimicrobial Agents·Philippe GautretDidier Raoult
Apr 3, 2020·Médecine et maladies infectieuses·J M MolinaN de Castro
Citations
Aug 28, 2020·Frontiers in Microbiology·Siew L TeohShaun W H Lee
Jul 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga TarasovaVladimir Poroikov
Aug 20, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Haleh TalaieAli Firoozfar
Oct 14, 2020·Yeungnam University Journal of Medicine·Hyun Jung Kim
Jan 3, 2021·The International Journal of Risk & Safety in Medicine·Kavita ManchandaHarmanjit Singh
Nov 15, 2020·Expert Review of Anti-infective Therapy·Betsy Ann JosephKevin Kallmes
Feb 26, 2021·Biochemistry Research International· PurwatiYuni Indrayani
Mar 24, 2021·Journal of Korean Medical Science·Eun Jeong JooKyong Ran Peck
Apr 27, 2021·The Medical Journal of Australia·Paulina StehlikDavid A Henry
Jul 3, 2021·Life·Justyna Olszewska-ParasiewiczDariusz A Kosior
Jul 28, 2021·Journal of Chemical Information and Modeling·Balázs Zoltán ZsidóCsaba Hetényi
Aug 20, 2021·Infection & chemotherapy·Sun Bean KimUNKNOWN Korean Society of Infectious Diseases (KSID)
Nov 9, 2021·Nano Convergence·Han Na LeeBong Guen Chung
Nov 19, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Michael Takla, Kamalan Jeevaratnam
Jan 29, 2022·European Journal of Clinical Pharmacology·Mei Nee ChiuSangeeta Pilkhwal Sah