Lopinavir/ritonavir as a third agent in the antiviral regimen for SARS-CoV-2 infection.

Journal of Chemotherapy
Periklis PanagopoulosDimitrios Papazoglou

Abstract

Corona Virus Disease (CoVID-19) is an emerging public health problem rapidly spread globally. New treatment options for patients with severe symptoms and ways of reducing transmission in the community are taken into consideration. A retrospective study was conducted in the Department of Infectious Diseases of Alexandroupolis (Greece) including 16 patients with CoVID-19. They were classified into two groups, A and B. Group A received lopinavir/ritonavir as a third agent in the antiviral regimen, while group B did not. Lymphocytes were more significantly increased in patients of group A. Ferritin serum levels were also decreased significantly in these patients. Number of days needed for a first negative result of Real Time- Polymerase Chain Reaction (RT-PCR) was lower for Group A. The present study suggests that lopinavir/ritonavir may reduce the viral carriage in a shorter period of time compared with other antiviral regimens. Further studies are needed in order to evaluate the effectiveness of lopinavir/ritonavir in the treatment of patients with SARS-CoV-2 infection.

References

Nov 1, 2003·The Lancet Infectious Diseases·Andrea SavarinoRoberto Cauda
Apr 29, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P PanagopoulosH Giamarellou
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Jan 31, 2020·Bioscience Trends·Hongzhou Lu
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang
Mar 25, 2020·International Journal of Antimicrobial Agents·Philippe GautretDidier Raoult

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Citations

Jul 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga TarasovaVladimir Poroikov
Aug 28, 2020·Frontiers in Microbiology·Siew L TeohShaun W H Lee
Nov 15, 2020·Expert Review of Anti-infective Therapy·Betsy Ann JosephKevin Kallmes
May 1, 2021·Microorganisms·Seri JoDong Hae Shin

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Methods Mentioned

BETA
Polymerase Chain Reaction

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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