Lopinavir/ritonavir in pregnancy

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Susan S RobertsWilliam C Woodward

Abstract

The Antiretroviral Pregnancy Registry was established in 1989 to collect data on birth defects after pregnancy exposures to antiretroviral therapy. Using Registry data, this study estimates the birth defect risk after pregnancy exposures to lopinavir/ritonavir. The analysis population includes all prospective lopinavir/ritonavir-exposed pregnancies enrolled in the Registry from September 2000 through July 2007. Birth defect prevalence after pregnancy exposure is compared with rates from a population-based surveillance system, and first-trimester exposures are compared with combined second/third-trimester exposures. Among 955 live births prenatally exposed to lopinavir/ritonavir, 23 cases with birth defects were reported [2.4%, 95% confidence interval (CI) = 1.5 to 3.6). Among 267 live births with first-trimester exposures, 5 had birth defects (1.9%, 95% CI = 0.6 to 4.3). These rates are similar to the population-based comparator rate of 2.67% and the rate in infants with second/third-trimester exposures (2.6%, 95% CI = 1.6 to 4.1). No pattern of birth defects suggestive of a common etiology was seen. The prevalence of birth defects among infants prenatally exposed to lopinavir/ritonavir is not significantly different from inter...Continue Reading

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Citations

Feb 14, 2013·Drugs·Nisha Andany, Mona R Loutfy
Sep 4, 2010·Indian Journal of Pediatrics·Mamatha M Lala, Rashid H Merchant
Mar 15, 2019·HIV Medicine·Dr Yvonne GilleeceMs Alison Wright
Oct 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Antonella d'Arminio MonforteUNKNOWN ICONA Foundation Study Group
Apr 22, 2015·The Pediatric Infectious Disease Journal·Sara SollaiElena Chiappini
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Apr 25, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Xiaoxuan ZhaoXiaoling Feng
Jun 24, 2020·Frontiers in Microbiology·Youwen MeiYonghong Lin
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Jan 22, 2015·HIV Medicine·Annemiek de RuiterUNKNOWN British HIV Association
Jan 21, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nitalia NaidooThajasvarie Naicker
Jan 26, 2021·Geburtshilfe und Frauenheilkunde·Marcelo Borges CavalcanteEdward Araujo Júnior

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