Abstract
To evaluate the risk factors for lopinavir/ritonavir (LPV/r)-related liver enzyme elevation (LEE) in HIV antiretroviral-experienced patients. An open prospective observational study was carried out to analyse the incidence and time of LEE development during LPV/r treatment, and to determine whether LEE development was correlated with epidemiological, clinical and biochemical data, immune and virological profiles, concomitant hepatic diseases, antiretroviral therapy, or histological and ultrasonography liver examination results. A diagnosis of LEE was considered when LEE symptoms occurred after LPV/r introduction and was confirmed by a second control within 2 weeks. A total of 782 HIV-positive outpatients have been enrolled in six different Infectious Diseases Departments in Northern Italy since August 2000. Of these patients, 71 (9.1%) developed LEE within 115+/-85 days (mean+/-standard deviation); 13 of these subjects discontinued LPV/r and four were hospitalized. Of the patients with LEE, 74.6% and 25.4% had grade 2 and > or =3 toxicity, respectively. No correlation between LEE and sex, baseline CD4 cell count, viral load, HIV stage, triglyceride values, histological and ultrasonography liver examination results, nevirapine u...Continue Reading
References
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jul 1, 1993·The Journal of Experimental Medicine·M A MinutelloS Abrignani
Jul 1, 1997·Journal of Hepatology·J OckengaR E Schmidt
Jul 11, 1998·JAMA : the Journal of the American Medical Association·W G PowderlyM M Lederman
Sep 4, 1998·AIDS·S A ElliottJ D Ross
Dec 24, 1998·AIDS·M JohnM A French
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Cerny, F V Chisari
Dec 22, 1999·AIDS·M SavèsF Dabis
Jan 13, 2000·American Journal of Clinical Pathology·K G Ishak
Jan 13, 2000·JAMA : the Journal of the American Medical Association·M S SulkowskiR D Moore
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H MarusawaT Chiba
Nov 14, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E H GisolfUNKNOWN Prometheus Study Group
Jan 12, 2001·AIDS·M den BrinkerJ M Lange
Jun 27, 2001·AIDS·E MartínezJ M Gatell
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BenhamouUNKNOWN MultivirC Group
Oct 9, 2001·International Journal of STD & AIDS·J Arribas
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark S SulkowskiRichard D Moore
Apr 10, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Curtis L CooperJonathan B Angel
Jun 6, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marina NúñezVincent Soriano
Jul 20, 2002·AIDS·M RecheM C López Serrano
Jul 20, 2002·AIDS·Corinne RancinanUNKNOWN Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA)
Jul 20, 2002·AIDS·Luz Martín-CarboneroVincent Soriano
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David L Thomas
Nov 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F BonnetUNKNOWN French Aquitaine Cohort. Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA)
Nov 16, 2002·Pharmacotherapy·Robert Orenstein, Nickolaos Tsogas
Dec 7, 2002·Microbes and Infection·Mandana Khalili, Brian W Behm
Aug 6, 2011·Antiviral Therapy·Wouter F W BiermanMichiel A van Agtmael
Citations
Oct 17, 2007·Digestive Diseases and Sciences·Richard K SterlingDaniel Nixon
Jul 20, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A F T B GouveaR C M Succi
Jun 22, 2010·AIDS Research and Human Retroviruses·Keith W CrawfordUNKNOWN AIDS Clinical Trials Protocol 5015 Team
Jul 27, 2007·AIDS Patient Care and STDs·S ChihrinM R Loutfy
Feb 1, 2012·The Journal of Infectious Diseases·Jennifer C PriceChloe L Thio
Aug 17, 2005·AIDS·Paolo BonfantiUNKNOWN CISAI Study Group
Oct 13, 2012·Journal of Clinical Gastroenterology·Richard K SterlingElizabeth M Brunt
Feb 23, 2007·AIDS·Paola CicconiUNKNOWN ICoNA Study Group
Dec 20, 2007·AIDS·Vincent SorianoBarbara McGovern
Jul 16, 2005·BMC Infectious Diseases·Carlo TortiUNKNOWN EPOKA-MASTER Study Group
Jan 5, 2007·Clinical Pharmacokinetics·José MoltóBonaventura Clotet
Dec 3, 2014·Clinics in Liver Disease·Chathur AcharyaRichard K Sterling
Apr 5, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Jia-Jia ChenLan-Juan Li
Aug 29, 2007·Clinics in Liver Disease·Mamta K Jain
Oct 20, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yun WangHuiping Zhou
Apr 25, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R BrunoG Filice
Jan 2, 2007·HIV Clinical Trials·Rosario PalaciosJesús Santos
Dec 21, 2005·Journal of Hepatology·Marina Núñez
Dec 20, 2011·HIV Clinical Trials·José L CasadoSantiago Moreno
Aug 22, 2014·HIV Clinical Trials·Antonio Di Biagio For The Icona Foundation Study Group
Oct 14, 2006·Therapeutic Drug Monitoring·Martijn R van der LeurPeter P Koopmans
Sep 7, 2005·The Journal of Antimicrobial Chemotherapy·Elena SeminariAntonella Castagna
Mar 19, 2014·Therapeutic Drug Monitoring·Pavel KhaykinNils von Hentig
Jun 20, 2020·Journal of Medical Virology·Yang LiXuebing Yan
May 11, 2010·European Journal of Medical Research·F OrtuP E Manconi
Jun 20, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Xiaojing ZouJiao Huang
Dec 29, 2020·Clinical and Experimental Hypertension : CHE·Dong XiangDong Liu
Sep 16, 2020·European Journal of Pharmacology·Chuan-Feng TangLing-Dong Kong
Sep 18, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Joseph William ClintonJames H Lewis