PMID: 2377Jan 1, 1976

Lorazepam as a premedication

Canadian Anaesthetists' Society Journal
G Gale, S Galloon

Abstract

A double-blind random study compared the effects of lorazepam and pantopon an intra-muscular premedication in healthy women for uterine curettage (D & C). Anxiety, as assessed by a self-rating test by the patient and by a trained observer, showed a significant reduction at one and one-half hours after lorazepam and a smaller reduction after pantopon, which was not significant. Sedation was satisfactory with no significant difference between the two drugs in the change before and after the premedication. Lorazepam showed much more amnesia than pantopon (p less than 0.001). The patients who had lorazepam required higher doses of thiopentone for the operation, and this, in part, led to longer intervals in recovery times after lorazepam. However, it is suggested that lorazepam itself was partly responsible for the longer recovery. Pantopon was followed by more nausea, vomiting and headaches, than lorazepam. The intra-muscular injection of lorazepam hurt more patients than did pantopon, but other local complications were negligible and comparable in both groups. The results of this study show that lorazepam produces better reduction of anxiety and much more amnesia than pantopon, with comparable sedation and much less nausea and vom...Continue Reading

References

Jun 1, 1977·British Journal of Anaesthesia·W WassenaarG Gale
Mar 1, 1973·Anesthesia and Analgesia·W F Powell, W H Comer
Sep 1, 1973·Anaesthesia·N J Paymaster
May 1, 1971·Clinical Pharmacology and Therapeutics·H W ElliottW H Comer
Aug 1, 1971·British Journal of Anaesthesia·W Norris, P G Wallace
Apr 1, 1963·Anaesthesia·S A FELDMAN
Oct 1, 1963·British Journal of Anaesthesia·H I NISBET, W Norris

Citations

Mar 1, 1981·Canadian Anaesthetists' Society Journal·R DesjardinsJ Charest
Mar 1, 1983·Canadian Anaesthetists' Society Journal·R S Clarke
Jan 26, 2000·Journal of Cataract and Refractive Surgery·D M Harman
Feb 11, 1998·Journal of Cataract and Refractive Surgery·F D Ghanchi, M Y Khan
Aug 1, 1982·British Journal of Clinical Pharmacology·W A McGowan, J W Dundee

Related Concepts

Clinical Trials
Sedicepan
Memory
Nausea
Pantopon
Preanesthetic Medication
Psychological Tests (Procedure)
Anti-Anxiety Effect
Vomiting

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