PMID: 6104935Jan 1, 1980Paper

Lorazepam as night sedation and premedication: a comparison with diazepam

Anaesthesia
C Studd, R J Eltringham

Abstract

Fifty healthy female patients scheduled for surgery were randonly allocated into two groups in a double-blind study. One group received lorazepam 2.5 mg orally at 2200 h on the evening before surgery as night sedation, and again at 0800 h on the morning before surgery as premedication. The second group received diazepam 10 mg orally at the samte times. The quality of sleep the night before surgery was superior in the lorazepam group (p less than 0.02). The frequency of effective sedation produced pre-operatively was similar in both groups. Although the incidence of amnesia for visual stimuli following lorazapam was higher (p less than 0.05) than with diazepam, there was no difference in the recall of auditory and painful stimuli. The overall incidence of side effects was similar for each drug and at the dosage used no difference was found in the time to awaken from anaesthesia.

References

Oct 1, 1977·British Journal of Anaesthesia·J W DundeeK A George
May 1, 1978·British Journal of Anaesthesia·R R PaganoR L Katz
Oct 1, 1978·British Journal of Anaesthesia·M E Dodson, R J Eastley
Nov 1, 1978·British Journal of Anaesthesia·J M Hewitt, A M Barr
Jan 1, 1975·British Journal of Anaesthesia·D V Heisterkamp, P J Cohen
Feb 1, 1978·Anaesthesia·R K MirakhurJ R McDonald
Sep 1, 1973·Anaesthesia·N J Paymaster
Jan 1, 1973·Current Medical Research and Opinion·N J Paymaster
Mar 1, 1970·British Journal of Anaesthesia·J W Dundee, W H Haslett

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Citations

Apr 19, 2019·Journal of Maxillofacial and Oral Surgery·Vikas SharmaAkanksha Zutshi

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