PMID: 424Nov 1, 1975

Lorazepam compared with pentobarbital for nighttime sedation

Journal of Clinical Pharmacology
P J BrownC R Brown


Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in "hospital insomnia." Subjective-response data were collected by research nurses. Lorazepam was found to be a potent nighttime sedative: 1 to 1.25 mg of lorazepam is equivalent to 100 mg sodium pentobarbital for measures of sleep quality and duration. At this dose level it is less effective than 100 mg of pentobarbital as a sleep inducer. Studies at higher doses (up to 4 mg) indicate that lorazepam has a wide therapeutic index.


Sep 1, 1970·Archives of General Psychiatry·A KalesJ D Kales
Feb 4, 1974·JAMA : the Journal of the American Medical Association·A KalesJ D Kales
Aug 1, 1972·The Journal of Clinical Pharmacology and New Drugs·C R BrownW H Forrest
Mar 1, 1973·Anesthesia and Analgesia·W F Powell, W H Comer
Apr 1, 1974·Journal of Clinical Pharmacology·C R BrownW H Forrest
May 1, 1971·Clinical Pharmacology and Therapeutics·H W ElliottW H Comer


Related Concepts

Sedative Effect
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