Lorazepam in status epilepticus

Annals of Neurology
J E WalkerW G Tasker

Abstract

Lorazepam, a dichloro-3-hydroxy-1,4-benzodiazepine, has been shown to be a potent anticonvulsant in animal models of epilsepsy and has minimal depressant effects on respiration and circulation in humans. The effects of this compound were studied in status epilepticus. Twenty-five patients were given intravenous lorazepam during status epilepticus of varying cause. Four or 8 mg of the drug controlled status in 22 of the 25 patients. Although single seizures recurred in 5 of the 22 patients, none experienced recurrence of status during a prolonged follow-up period. Transient respiratory arrest occurred in 1 patient, but no other significant complications were observed. Studies of plasma drug levels suggest that most patients attain good seizure control at concentrations between 30 and 100 ng per milliliter. Clinical observations indicate that repetitive injections are not required for continuing control of seizures in patients whose seizures are initially controlled. Lorazepam appears to be an effective and safe drug for treatment of status epilepticus, with a duration of control longer than that achieved with diazepam.

References

Nov 1, 1984·Indian Journal of Pediatrics·K Venkataswarlu, S Mehta
Apr 25, 2012·Neurocritical Care·Gretchen M BrophyNeurocritical Care Society Status Epilepticus Guideline Writing Committee
Dec 1, 1981·Electroencephalography and Clinical Neurophysiology·A ValinR Naquet
Nov 1, 1987·Pediatric Neurology·N M Graves, R L Kriel
Nov 1, 1988·Pediatric Neurology·D W Giang, M C McBride
Sep 1, 1992·Epilepsy Research·N Y Walton, D M Treiman
May 19, 2001·Neurologic Clinics·B J Smith
Jun 3, 1982·The New England Journal of Medicine·A V Delgado-EscuetaR J Porter
Oct 28, 1982·The New England Journal of Medicine
Aug 18, 1983·The New England Journal of Medicine·D J GreenblattD R Abernethy
Jan 1, 1983·Journal of Psychoactive Drugs·J G Botvin Madorsky
Sep 9, 1999·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·P W Kaplan
Jun 17, 2003·The Neurologist·John N Gaitanis, Frank W Drislane
Jan 1, 1982·Epilepsia·A V Delgado-Escueta, J G Bajorek
Jan 1, 1987·Epilepsia·W E Dodson
Mar 21, 2002·Emergency Medicine Journal : EMJ·A S Lockey
Feb 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·A Moffett, D F Scott
Aug 28, 2002·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Nicholas D Lawn, Eelco F M Wijdicks
May 1, 1988·Medical Toxicology and Adverse Drug Experience·B AdinoffM Linnoila
Jul 20, 2007·British Journal of Clinical Pharmacology·Simon N MuchohiGilbert O Kokwaro
Jan 1, 1984·The Journal of Emergency Medicine·D B McMicken
Sep 1, 1993·The Journal of Emergency Medicine·E S Freedland, D B McMicken
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·D R AbernethyR I Shader
Jan 1, 1983·British Journal of Clinical Pharmacology·G TedeschiA Richens
May 1, 1986·The Journal of Pediatrics·D J LaceyH Gilmore
Mar 1, 1992·The Journal of Pediatrics·C A McDermottS Metrick
Sep 17, 2011·Clinical Trials : Journal of the Society for Clinical Trials·Valerie DurkalskiDaniel Lowenstein
Sep 10, 2016·Epilepsy & Behavior : E&B·Sheryl R HautJohn Pellock
Feb 9, 2017·Praxis·Dominique Flügel
Nov 1, 1981·Acta Neurologica Scandinavica·D F Scott, A Moffett
Aug 1, 1995·Developmental Medicine and Child Neurology·R AppletonE Molyneux
Apr 1, 1991·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·L B Warneke

Citations

Aug 1, 1977·Journal of Clinical Pharmacology·D J GreenblattH W Ruelius
Oct 1, 1973·The American Journal of the Medical Sciences·D J Greenblatt, J Koch-Weser
May 1, 1971·Clinical Pharmacology and Therapeutics·H W ElliottW H Comer
Apr 1, 1969·Neurology·C F NicolB H Smith

Related Concepts

Sedicepan
Status Epilepticus
Anti-Anxiety Effect
Simple Partial Status Epilepticus

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