PMID: 8959471Dec 1, 1996Paper

Lorazepam reduces cardiac vagal modulation in normal subjects

Journal of Clinical Psychopharmacology
L R VogelR P Sloan

Abstract

Benzodiazepines are frequently administered postmyocardial infarction, but their effect on heart period variability (HPV), a prognostic index of sudden arrhythmogenic death, is unclear. In fact, in both humans and animals, previous studies utilizing acute intravenous doses yielded mixed results. We hypothesized that lorazepam (LZ), by potentiating gamma-aminobutyric acid-A-ergic inhibition of preganglionic vagal neurons projecting to the heart, would reduce cardiac vagal modulation. We therefore tested LZ's effect on HPV over 24 hours of normal physiologic activity in human volunteers in the presence of steady-state LZ. A double-blind, randomized, placebo-controlled study was conducted. Seven healthy subjects received LZ or placebo for 1 week, 1 week taper, then crossed over. Electrocardiogram recordings measured HPV after the administration of drug and placebo for 24 hours. LZ increased mean heart rate by 8% (p < 0.002), decreased the standard deviation of R-R intervals by 9% (p < 0.05), decreased the percent differences between adjacent normal R-R intervals > 50 msec by 30% (p < 0.002), decreased the root-mean-square successive difference by 17% (p < 0.02), and decreased the natural logarithm of high-frequency power by 6% (p ...Continue Reading

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Citations

Jan 8, 1999·Journal of the Neurological Sciences·M W AgelinkE Klieser
Dec 19, 2008·American Journal of Therapeutics·Jamil DarroujRohit Arora
Sep 17, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·A BirkhoferG Schmidt
Mar 17, 2007·Autonomic Neuroscience : Basic & Clinical·Markus BéchirGeorg Noll
May 12, 2004·Epilepsy Research·Claudia Stöllberger, Josef Finsterer
Jul 30, 2014·Frontiers in Psychiatry·John A ChalmersAndrew H Kemp
Apr 12, 2005·Journal of Cardiovascular Pharmacology·Allyson J Bennett, Paolo B DePetrillo
Oct 25, 2017·European Heart Journal. Acute Cardiovascular Care·Sammy ZakariaNisha Chandra-Strobos
Jan 25, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andreas R SchwerdtfegerGert Pfurtscheller

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