Lorentz effect imaging of ionic currents in solution

Journal of Magnetic Resonance
Trong-Kha TruongAllen W Song

Abstract

Current functional MRI techniques relying on hemodynamic modulations are inherently limited in their ability to accurately localize neural activity in space and time. To address these limitations, we previously proposed a novel technique based on the Lorentz effect and demonstrated its ability to directly image minute electrical activity with a millisecond temporal resolution in gel phantoms containing conductive wires as well as in the human median nerve in vivo. To better characterize its contrast mechanism and ultimately further improve its sensitivity for in vivo applications, we now apply this technique to image ionic currents in solution, which serve as a better model for neural conduction in biological systems than the electronic currents in conductive wires used in previous phantom studies. Our results demonstrate that ionic currents with durations and current densities on the same order of magnitude as those induced by neuroelectric activity in nerve fibers and in the brain can be detected.

References

Mar 4, 1999·Journal of Magnetic Resonance·J BodurkaS J Li
Sep 12, 2001·Magnetic Resonance Imaging·A W Song, A M Takahashi
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jerzy Bodurka, Peter A Bandettini
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel KonnRichard Bowtell
Feb 15, 2005·Magnetic Resonance Imaging·Daniel KonnRichard Bowtell
Dec 14, 2005·Journal of Magnetic Resonance·Trong-Kha TruongAllen W Song
Aug 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Trong-Kha Truong, Allen W Song
Oct 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Natalia PetridouPeter A Bandettini
Jan 30, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Laura M ParkesDavid G Norris
Jun 5, 2007·NeuroImage·K B BlagoevE Halgren
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Qingfei LuoJia-Hong Gao
Jul 27, 2007·Journal of Magnetic Resonance Imaging : JMRI·Li Sze ChowMartyn N J Paley

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Citations

Sep 24, 2013·Journal of Magnetic Resonance·Navid PourtaheriCraig S Henriquez
Feb 16, 2011·Experimental Biology and Medicine·Bradley J Roth
Feb 24, 2016·NeuroImage·Padmavathi SundaramYoshio Okada
May 10, 2011·Magnetic Resonance Imaging·Padmavathi SundaramDarren B Orbach
Mar 20, 2010·Journal of Magnetic Resonance·Ranjith S Wijesinghe, Bradley J Roth
Dec 20, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bradley J Roth, Peter J Basser
Jul 6, 2011·NMR in Biomedicine·Alexander J PoplawskyXiaoping P Hu
Sep 2, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Padmavathi SundaramDarren B Orbach
Oct 3, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mukund BalasubramanianDarren B Orbach
Apr 9, 2020·Journal of Neural Engineering·Bragi SveinssonMatthew S Rosen
May 1, 2018·Biomedical Physics & Engineering Express·Fanrui FuRosalind Sadleir

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