Losartan, an angiotensin-II receptor antagonist, retards the progression of advanced renal insufficiency

The Tohoku Journal of Experimental Medicine
Hiroshi OsawaKen Okumura

Abstract

Chronic renal disease with elevated level of serum creatinine (Cr) often progresses to end-stage renal disease. Although blockade of the renin-angiotensin system has been shown to slow the progression of chronic renal disease, it remains uncertain whether one could expect such a renoprotective effect even when the treatment is initiated late in the course of renal disease. The purpose of the present study was to examine the effect of losartan, an angiotensin-II receptor antagonist, on the progression of advanced renal insufficiency. We retrospectively analyzed eight hypertensive patients, whose baseline Cr levels exceeded 2.0 mg/dl (2.2-5.5); the subjects included 6 non-diabetic glomerular diseases, 1 diabetic nephropathy and 1 polycystic kidney disease. Losartan was given at the dosage of 25-50 mg/day. Changes in mean blood pressure (MBP) and serum levels of Cr, potassium (K) and uric acid were evaluated after treatment for 24 weeks. Slopes of reciprocal of serum Cr plotted against time (1/sCr slope), which indicate the rate of renal function loss before and after the treatment period, were compared. There was a significant reduction of 1/sCr slope after losartan (-0.004 +/- 0.002 dl/mg/week before and -0.001 +/- 0.002 dl/mg/w...Continue Reading

References

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Citations

Apr 17, 2007·Lancet·Vicente E TorresYves Pirson
Jun 24, 2010·Archives of Gerontology and Geriatrics·Massimo MottaGiovanni Pennisi
May 28, 2011·The Tohoku Journal of Experimental Medicine·Hisashi MasugataFuminori Goda
Oct 31, 2020·International Journal of Immunopathology and Pharmacology·Rabia ZahidEjaz Rafique

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