Losartan blocks aldosterone and renal vascular responses to angiotensin II in humans

Hypertension
S K GandhiN J Brown

Abstract

In vitro and animal studies have demonstrated that the effect of angiotensin II (Ang II) on aldosterone is mediated through the Ang II type 1 receptor. However, it has been difficult to demonstrate an effect of Ang II type 1 receptor blockade on aldosterone levels in human studies. One possible explanation is that subjects have not been studied under salt-controlled conditions. Therefore, we examined the effects of losartan on the aldosterone and renal plasma flow responses to Ang II infusion in six normotensive subjects under low and high salt conditions. Ang II was infused in graded doses (0.3 to 10 ng/kg per minute) in the presence and absence of losartan (a single 50-mg oral dose). Renal plasma flow was assessed by measurement of para-aminohippurate clearance. Blood pressure, plasma aldosterone levels (low salt conditions only), and para-aminohippurate clearance were measured before and after each Ang II dose. Losartan had no effect on baseline systolic pressure but attenuated the systolic pressure response to exogenous Ang II during both low salt (0.7 +/- 1.9 versus 6.7 +/- 1.4 mm Hg, P = .001) and high salt (2.0 +/- 1.9 versus 12.3 +/- 2.1 mm Hg, P = .006) conditions. Under low salt conditions, losartan reduced the baseli...Continue Reading

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Citations

Aug 21, 2002·Current Opinion in Nephrology and Hypertension·Domenic A Sica, Anton C Schoolwerth
Mar 19, 2005·Journal of Hypertension·Wilko SpieringPeter W de Leeuw
Apr 12, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·John P Collister, David B Nahey
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·X H WuJ S Chan
Jul 28, 1999·Clinical and Experimental Hypertension : CHE·A MimranG DuCailar
May 28, 2010·The Journal of Pharmacology and Experimental Therapeutics·Almerina BiggiAlberto Montanari
May 10, 2013·American Journal of Physiology. Renal Physiology·Alberto MontanariDavid Z Cherney
Jan 17, 2014·American Journal of Physiology. Renal Physiology·Kevin L Gordish, William H Beierwaltes
Mar 31, 2021·High Altitude Medicine & Biology·John P DelamereArthur R Bradwell

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