Losartan influences behavioural effects of angiotensin II(3-7) in rats

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
W Karwowska-PoleckaJ J Braszko

Abstract

We have previously shown that angiotensin II(3-7) [Ang II(3-7)] stimulates behavioural activity of rats similar to angiotensin II (Ang II). The involvement of AT1 angiotensin receptors in stimulating the behavioural activity of rats, using their selective ligand losartan (DUP 753), was examined. Ang II(3-7), given intracerebroventricularly (i.c.v.) at a dose of 1 nmol, significantly enhanced recall of a passive avoidance behaviour, object recognition, learning of conditioned avoidance responses (CARs) and apomorphine (1 mg kg-1, i.p.) stereotypy. Losartan (1 microgram, i.c.v.) did not alter any of the behaviours except for that measuring anxiety which was diminished both, in peptide treated and in control rats. On the other hand, losartan abolished Ang II(3-7) facilitation of recall of the passive avoidance, object recognition and the increase in apomorphine stereotypy. Losartan did not influence the increased rate of CARs acquisition after the peptide. None of the treatments significantly changed locomotor activity estimated in an open field. These data point to some involvement of AT1 angiotensin receptors in the behavioural activity of Ang II(3-7).

Citations

Mar 22, 2002·European Journal of Pharmacology·Paul R Gard
Sep 29, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ana Cristina Simões E Silva, Joseph T Flynn
Mar 5, 2004·Expert Opinion on Therapeutic Targets·Paul R Gard
Jun 18, 2010·European Journal of Pharmacology·Bruno J D GoldingPaul R Gard
Mar 14, 2007·Regulatory Peptides·Patrícia Maria FerreiraMaria José Campagnole-Santos
Jun 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·F MudersK Jandeleit-Dahm
Jun 24, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M M Winnicka, K Wisniewski
Feb 18, 2004·Hypertension·Nelson Ruiz-OpazoJohn Tonkiss
Apr 3, 2019·Journal of Cardiovascular Development and Disease·Ali NehmeKazem Zibara
Jul 20, 2021·Biological Psychiatry·Murray B SteinUNKNOWN LOSe-PTSD Investigators

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