Losartan Prevents Maladaptive Auditory-Somatosensory Plasticity After Hearing Loss via Transforming Growth Factor-β Signaling Suppression

Clinical and Experimental Otorhinolaryngology
Seog-Kyun MunMun Young Chang

Abstract

Hearing loss disrupts the balance of auditory-somatosensory inputs in the cochlear nucleus (CN) of the brainstem, which has been suggested to be a mechanism of tinnitus. This disruption results from maladaptive auditory-somatosensory plasticity, which is a form of axonal sprouting. Axonal sprouting is promoted by transforming growth factor (TGF)-β signaling, which can be inhibited by losartan. We investigated whether losartan prevents maladaptive auditory-somatosensory plasticity after hearing loss. The study consisted of two stages: determining the time course of auditory-somatosensory plasticity following hearing loss and preventing auditory-somatosensory plasticity using losartan. In the first stage, rats were randomly divided into two groups: a control group that underwent a sham operation and a deaf group that underwent cochlea ablation on the left side. CNs were harvested 1 and 2 weeks after surgery. In the second stage, rats were randomly divided into either a saline group that underwent cochlear ablation on the left side and received normal saline or a losartan group that underwent cochlear ablation on the left side and received losartan. CNs were harvested 2 weeks after surgery. Hearing was estimated with auditory brai...Continue Reading

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Citations

Dec 13, 2019·International Journal of Audiology·Haúla F HaiderLuís-Miguel Borrego
Aug 23, 2019·International Journal of Molecular Medicine·Kyu-Hee HanMunyoung Chang
Nov 26, 2020·International Journal of Molecular Sciences·Sohyeon ParkMoo Kyun Park
Jul 11, 2020·Clinical and Experimental Otorhinolaryngology·Seog-Kyun MunMunyoung Chang

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