Losartan reduces phenylephrine constrictor response in aortic rings from spontaneously hypertensive rats. Role of nitric oxide and angiotensin II type 2 receptors

Hypertension
R MaesoV Cachofeiro

Abstract

Nitric oxide seems to be involved in the mechanisms underlying the antihypertensive and renal responses of losartan in spontaneously hypertensive rats (SHR). We investigated the contribution of nitric oxide to the effect of this angiotensin II (Ang II) type 1 (AT1) receptor antagonist on the constrictor response of phenylephrine in aortic rings from SHR. Furthermore, since it has been suggested that Ang II could bind to unblocked AT2 receptors, during administration of an AT1 receptor antagonist, we also studied the effect of the AT2 receptor antagonist PD 123319 on the contractile response to phenylephrine in aortic rings from SHR. To this end, we studied dose-response curves of phenylephrine (10(-9) to 10(-5) mol/L) in the presence and absence of losartan (10(-9), 10(-7), and 10(-5) mol/L) in SHR aortic rings. Preincubation with losartan reduced the constrictor response to phenylephrine but not to KCl (10 to 120 mmol/L) in a dose-dependent manner. On the other hand, the presence of captopril (10(-5) mol/L) in the incubation medium did not alter the response to phenylephrine, even at the dose of 10(-3) mol/L. The reduced response to phenylephrine in the presence of losartan was abolished in both endothelium-denuded rings and r...Continue Reading

References

Apr 11, 1991·American Journal of Hypertension·A T ChiuP B Timmermans
Jul 1, 1987·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·J Ziogas, D F Story
Jan 1, 1995·Brain Research Bulletin·A IsraelJ M Saavedra

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Citations

Nov 27, 2004·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·V ThirunavukkarasuC V Anuradha
Sep 12, 2000·Current Hypertension Reports·S TaddeiA Salvetti
Sep 12, 2000·Current Hypertension Reports·H M Siragy, M Bedigian
May 23, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Xiao-Chen RuQiang Xia
Jul 13, 2000·Journal of Cardiovascular Pharmacology·K HaradaA Fujimura
Nov 26, 2003·Journal of Cardiovascular Pharmacology·Tomasz MatysWlodzimierz Buczko
Dec 20, 2007·Journal of Cardiovascular Pharmacology·Hoang ThaiMohamed A Gaballa
Apr 5, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Amy C ArnoldDebra I Diz
Aug 6, 2009·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Natalia de las HerasVicente Lahera
Nov 17, 1998·Clinical and Experimental Hypertension : CHE·L G HegdeM Dikshit
Aug 30, 2005·Blood Pressure·Luis M RuilopeFaiez Zannad
Sep 1, 2015·Pharmacological Reports : PR·Karol KramkowskiWlodzimierz Buczko
Jul 24, 2013·International Journal of Vascular Medicine·Nurul Maizan ManshorZurina Hassan
Nov 13, 2009·Diabetes Care·Daniele VersariStefano Taddei
May 26, 2016·Life Sciences·Mónica Moreira-RodriguesDaniel Moura
Aug 16, 2016·Biochemical and Biophysical Research Communications·Narumi Hashikawa-Hobara, Naoya Hashikawa
Oct 28, 2016·Drugs·Alan C CameronRhian M Touyz
Jul 23, 2003·Journal of Hypertension·Massimo VolpeAlberto Morganti

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