Losigamone decreases spontaneous synaptic activity in cultured hippocampal neurons

European Journal of Pharmacology
A DraguhnU Heinemann

Abstract

Losigamone is a new antiepileptic drug with an unknown mechanism of action. Here we report on the effects of losigamone on the synaptic activity in a network of cultured rat hippocampal neurons. Losigamone dose dependently reduced the frequency of spontaneous synaptic events without affecting the mean current amplitude. The drug affected equally the isolated inhibitory as well as excitatory postsynaptic currents. Miniature postsynaptic currents were not altered by losigamone, suggesting that the mechanism of action depends on functional Na+ channels. Consistent with these findings, the drug decreased the frequency of spontaneous action potentials and suppressed repetitive firing of neurons. Thus, losigamone generally depresses synaptic activity in a neuronal network without selectively modulating a specific postsynaptic receptor type. We conclude that losigamone acts via a presynaptic mechanism reducing neuronal excitability.

References

May 13, 1977·Brain Research·G A Banker, W M Cowan
Jan 1, 1991·Epilepsy Research. Supplement·U SteinS S Chatterjee
Aug 19, 1985·Brain Research·T J Blaxter, P L Carlen
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Dec 1, 1994·Trends in Neurosciences·I ModyI Soltesz
Jun 1, 1993·Trends in Neurosciences·S M ThompsonM Scanziani
Dec 24, 2003·Radiation Protection Dosimetry·J G R JefferysJ Fox

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Citations

Nov 9, 2002·Epilepsia·Rüdiger Köhling
Dec 12, 2001·CNS Drugs·A Nicolson, J P Leach
May 16, 2009·Pharmacological Reports : PR·Jarogniew J Luszczki
Dec 19, 2012·Epilepsia·Pablo M Casillas-EspinosaTerence J O'Brien
Jan 5, 2001·Expert Opinion on Investigational Drugs·M C Walker, J W Sander
May 21, 2013·Seizure : the Journal of the British Epilepsy Association·L John Greenfield
Jan 23, 2018·The Cochrane Database of Systematic Reviews·Yousheng XiaoHongye Luo
Dec 15, 2015·The Cochrane Database of Systematic Reviews·Yousheng XiaoHongye Luo
Dec 12, 2019·The Cochrane Database of Systematic Reviews·Hongchang ChenJin Wang
Mar 13, 2008·Bioorganic & Medicinal Chemistry·Rainer Schobert, Andrea Schlenk

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