Loss anticipation and outcome during the Monetary Incentive Delay Task : a neuroimaging systematic review and meta-analysis
Abstract
Reward seeking and avoidance of punishment are key motivational processes. Brain-imaging studies often use the Monetary Incentive Delay Task (MIDT) to evaluate motivational processes involved in maladaptive behavior. Although the bulk of research has been done on the MIDT reward events, little is known about the neural basis of avoidance of punishment. Therefore, we conducted a meta-analysis of brain activations during anticipation and receipt of monetary losses in healthy controls. All functional neuro-imaging studies using the MIDT in healthy controls were retrieved using PubMed, Google Scholar & EMBASE databases. Functional neuro-imaging data was analyzed using the Seed-based d Mapping Software. Thirty-five studies met the inclusion criteria, comprising 699 healthy adults. In both anticipation and loss outcome phases, participants showed large and robust activations in the bilateral striatum, (anterior) insula, and anterior cingulate gyrus relatively to Loss > Neutral contrast. Although relatively similar activation patterns were observed during the two event types, they differed in the pattern of prefrontal activations: ventro-lateral prefrontal activations were observed during loss anticipation, while medial prefrontal act...Continue Reading
References
Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine.
Neuroplasticity in the mesolimbic system induced by natural reward and subsequent reward abstinence.
Risky decisions and their consequences: neural processing by boys with Antisocial Substance Disorder
Citations
Neural activation to loss and reward among alcohol naive adolescents who later initiate alcohol use.
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