Loss of ability to self-heal malaria upon taurine transporter deletion.

Infection and Immunity
Denis DelicFrank Wunderlich

Abstract

Deletion of the taurine transporter gene (taut) results in lowered levels of taurine, the most abundant amino acid in mammals. Here, we show that taut-/- mice have lost their ability to self-heal blood-stage infections with Plasmodium chabaudi malaria. All taut-/- mice succumb to infections during crisis, while about 90% of the control taut(+/+) mice survive. The latter retain unchanged taurine levels even at peak parasitemia. Deletion of taut, however, results in the lowering of circulating taurine levels from 540 to 264 micromol/liter, and infections cause additional lowering to 192 micromol/liter. Peak parasitemia levels in taut-/- mice are approximately 60% higher than those in taut(+/+) mice, an elevation that is associated with increased systemic tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels, as well as with liver injuries. The latter manifest as increased systemic ammonia levels, a perturbed capacity to entrap injected particles, and increased expression of genes encoding TNF-alpha, IL-1beta, IL-6, inducible nitric oxide synthase (iNOS), NF-kappaB, and vitamin D receptor (VDR). Autopsy reveals multiorgan failure as the cause of death for malaria-infected taut-/- mice. Our data indicate t...Continue Reading

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Citations

Dec 1, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rhea LongleyPhilippe Gros
Nov 19, 2010·Parasitology Research·Denis DelićFrank Wunderlich
Jun 27, 2013·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Florian LangMichael Föller
Oct 9, 2012·Biochimica Et Biophysica Acta·Jung-Hwan KimFrank J Gonzalez
Nov 20, 2014·Frontiers in Microbiology·Frank WunderlichMohamed A Dkhil
May 6, 2014·Frontiers in Physiology·Stephen A KempsonNiels C Danbolt
May 20, 2011·American Journal of Physiology. Cell Physiology·Elisabeth LangFlorian Lang
Apr 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia M WunderlichF Thomas Wunderlich
May 18, 2018·Animal Science Journal = Nihon Chikusan Gakkaihō·Nanae SasagoYoshinobu Uemoto
Jan 31, 2020·Malaria Journal·Denis DelicMarcos J Araúzo-Bravo
Sep 23, 2020·Nutrients·Tawar QaradakhiAnthony Zulli

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