Loss of Adipocyte VEGF Impairs Endurance Exercise Capacity in Mice

Medicine and Science in Sports and Exercise
Nicole J ZachwiejaI Mark Olfert

Abstract

Reducing vascular endothelial growth factor (VEGF) in adipose tissue alters adipose vascularity and metabolic homeostasis. We hypothesized that this would also affect metabolic responses during exercise-induced stress and that adipocyte-specific VEGF-deficient (adipoVEGF-/-) mice would have impaired endurance capacity. Endurance exercise capacity in adipoVEGF-/- (n = 10) and littermate control (n = 11) mice was evaluated every 4 wk between 6 and 24 wk of age using a submaximal endurance run to exhaustion at 20 m·min(-1) at 10° incline. Maximal running speed, using incremental increases in speed at 30-s intervals, was tested at 25 and 37 wk of age. White and brown adipose tissue capillarity were reduced by 40% in adipoVEGF-/-, and no difference in skeletal muscle capillarity was observed. Endurance run time to exhaustion was 30% lower in adipoVEGF-/- compared with that in controls at all time points (P < 0.001), but no difference in maximal running speed was observed between the groups. After exercise (1 h at 50% maximum running speed), adipoVEGF-/- mice displayed lower circulating insulin (P < 0.001), lower glycerol (P < 0.05), and tendency for lower blood glucose (P = 0.06) compared with controls. There was no evidence of alte...Continue Reading

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Citations

Sep 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Bruna B BrandãoMarcelo A Mori
Mar 27, 2018·Journal of Cachexia, Sarcopenia and Muscle·Paulo V G AlabarseRicardo M Xavier
Jun 6, 2020·Journal of Applied Physiology·Caroline de Carvalho PicoliSidney Barnabé Peres
Sep 9, 2017·International Journal of Experimental Pathology·Fernanda O DuarteHeloisa S Selistre-de-Araújo

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