Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression

Chemico-biological Interactions
Sergey A Krupenko, Natalia I Krupenko

Abstract

ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is the enzyme in folate metabolism commonly downregulated in human cancers. One of the mechanisms of the enzyme downregulation is methylation of the promoter of the ALDH1L1 gene. Recent studies underscored ALDH1L1 as a candidate tumor suppressor and potential marker of aggressive cancers. In agreement with the ALDH1L1 loss in cancer, its re-expression leads to inhibition of proliferation and to apoptosis, but also affects migration and invasion of cancer cells through a specific folate-dependent mechanism involved in invasive phenotype. A growing body of literature evaluated the prognostic value of ALDH1L1 expression for cancer disease, the regulatory role of the enzyme in cellular proliferation, and associated metabolic and signaling cellular responses. Overall, there is a strong indication that the ALDH1L1 silencing provides metabolic advantage for tumor progression at a later stage when unlimited proliferation and enhanced motility become critical processes for the tumor expansion. Whether the ALDH1L1 loss is involved in tumor initiation is still an open question.

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·K M ChampionC S Giometti
Jan 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R Bertino
Mar 12, 1998·International Journal of Cancer. Journal International Du Cancer·Y M ChenP H Chen
Jun 16, 2001·Journal of Applied Physiology·J J Brault, R L Terjung
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·S RamaswamyT R Golub
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Oct 1, 2003·The Journal of Biological Chemistry·Julie L Bronder, Richard G Moran
Jul 22, 2004·Molecular & Cellular Proteomics : MCP·L Elaine EppersonSandra L Martin
Aug 10, 2004·Nutrition Reviews·Patrick J Stover
Jul 15, 2005·The Biochemical Journal·Natalia V OleinikSergey A Krupenko
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Feb 14, 2006·Proteomics·Jean-François LéonardJean-Charles Gautier
Apr 7, 2006·Protein Science : a Publication of the Protein Society·Steven N ReulandSergey A Krupenko
Apr 22, 2006·The Journal of Biological Chemistry·Montserrat C AngueraPatrick J Stover
May 23, 2006·Biochemical Pharmacology·Natalia V OleinikSergey A Krupenko
Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yu-Chuen HuangYi-Ming Arthur Chen
May 25, 2007·Nature Reviews. Cancer·Weigang WangJohn Condeelis
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Victoria L StevensEugenia E Calle
Sep 22, 2007·The Journal of Biological Chemistry·Henry DonatoSergey A Krupenko
Sep 25, 2007·Human Genetics·Kyoung-Mu LeeBruce K Armstrong
Mar 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Luz Martínez-ChantarJosé M Mato
Jul 10, 2008·Expert Opinion on Drug Metabolism & Toxicology·Satori A MarchittiVasilis Vasiliou
Sep 23, 2008·Vitamins and Hormones·Jennifer T Fox, Patrick J Stover
Oct 14, 2008·Chemico-biological Interactions·Sergey A Krupenko
Dec 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Victoria L StevensEugenia E Calle
Feb 10, 2009·Current Opinion in Genetics & Development·Xuemei TongCraig B Thompson
Mar 12, 2009·Molecular Cancer Research : MCR·Feng JiangRuth L Katz
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Aug 27, 2009·Journal of Proteome Research·Anne-Françoise RénertMarianne Fillet
Nov 26, 2009·The Journal of Biological Chemistry·Kyle C StricklandSergey A Krupenko
Dec 5, 2009·Best Practice & Research. Clinical Haematology·Joseph R Bertino
May 26, 2010·The Journal of Biological Chemistry·Natalia I KrupenkoSergey A Krupenko
Jul 22, 2010·Annual Review of Nutrition·Anne S Tibbetts, Dean R Appling
Jan 11, 2011·Chemico-biological Interactions·Kyle C StricklandSergey A Krupenko

❮ Previous
Next ❯

Citations

Oct 19, 2019·Scientific Reports·Natalia I KrupenkoSergey A Krupenko
Nov 19, 2019·Frontiers in Genetics·Sergey A Krupenko, David A Horita
Sep 20, 2020·BMC Medical Genomics·Anna V KudryavtsevaAnastasiya V Snezhkina
Oct 9, 2020·Signal Transduction and Targeted Therapy·Huai-Qiang JuRui-Hua Xu
Jan 6, 2021·International Journal of Molecular Sciences·Qiyuan HanNatalia Y Tretyakova
Nov 12, 2020·Cancers·Mari PalviainenPia Siljander
Apr 14, 2020·Chemico-biological Interactions·Jaspreet Sharma, Sergey A Krupenko
Apr 30, 2021·Frontiers in Molecular Neuroscience·Fabrice BertileEtienne Challet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.