Loss of anteroposterior intralobar attenuation gradient of the lung: Correlation with pulmonary function

Academic Radiology
Mizuki NishinoHiroto Hatabu

Abstract

Since the initial description of an intralobar attenuation gradient by Webb et al, it has been suggested that departure from the intralobar attenuation gradient could indicate early lung diseases. However, its significance has not been determined in detail. We aimed to quantify the anteroposterior intralobar attenuation gradient on volumetric end-inspiratory and end-expiratory high-resolution computed tomography (CT) in patients with emphysema and to correlate the gradient values with pulmonary function. The study population consisted of 21 consecutive patients with emphysema evaluated with volumetric expiratory high-resolution CT and 6 patients with normal high-resolution CT findings. The anteroposterior intralobar attenuation gradient values were quantified on end-inspiratory and end-expiratory sagittal reformations using a lung analysis software program and were correlated with pulmonary function tests results. The intralobar attenuation gradient values in patients with forced expiratory volume in 1 second (FEV1) < or =70% were significantly smaller compared with those in patients with FEV1 >70% in bilateral lower lobes at end-expiration (P = .0061, P = .047, respectively, unpaired t-test). The FEV1 values in patients with a...Continue Reading

References

Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Jan 1, 1993·Radiology·W R WebbG Gamsu
Jun 1, 1996·Radiology·P A GevenoisJ C Yernault
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·S EdaF Sakai
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·R UppaluriG McLennan
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·Y NakanoJ C Hogg
Mar 25, 2004·AJR. American Journal of Roentgenology·Mizuki NishinoHiroto Hatabu
Oct 19, 2004·European Journal of Radiology·Mizuki Nishino, Hiroto Hatabu

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Citations

Jan 6, 2016·Expert Review of Respiratory Medicine·Bita HajianWilfried De Backer
Apr 10, 2010·Thoracic Surgery Clinics·Mizuki NishinoHiroto Hatabu
Dec 10, 2009·Radiologic Clinics of North America·Mizuki NishinoHiroto Hatabu
Aug 3, 2010·Journal of Magnetic Resonance Imaging : JMRI·Masaya TakahashiIvan Dimitrov

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