Loss of ARID1A Expression Correlates With Tumor Differentiation and Tumor Progression Stage in Pancreatic Ductal Adenocarcinoma

Technology in Cancer Research & Treatment
Li ZhangJie Chen

Abstract

Mutations in the AT-rich interactive domain 1A gene, which encodes a subunit of the Switch/Sucrose nonfermentable chromatin remodeling complex, can result in loss of protein expression and are associated with different cancers. Here, we used immunohistochemistry to investigate the significance of AT-rich interactive domain 1A loss in 73 pancreatic ductal adenocarcinoma cases with paired paracancerous normal pancreatic tissues. The relationship between levels of the AT-rich interactive domain 1A protein product, BAF250a, and clinicopathological parameters in the 73 pancreatic cancer specimens was also analyzed. We found that the expression of AT-rich interactive domain 1A in normal pancreatic tissue was higher than that in tumor tissue. Loss of AT-rich interactive domain 1A expression in pancreatic tumors was associated with tumor differentiation ( P = .002) and tumor stage ( P = .048). Meanwhile, BAF250a protein levels were not related to lymph node metastasis, distant metastasis, sex, or age and were not associated with survival. Transfection of the pancreatic cancer cell lines AsPC-1 and PANC-1 with small-interfering RNA specific for AT-rich interactive domain 1A resulted in elevated messenger RNA and protein expression level...Continue Reading

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Citations

Feb 8, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Noboru IdenoBidyut Ghosh
Jun 27, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Zhuandi GongSuocheng Wei
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Dec 22, 2020·PeerJ·Achira NamjanApinya Jusakul
Mar 7, 2021·International Journal of Molecular Sciences·Yolanda Rodríguez GilVíctor Javier Sánchez-Arévalo Lobo
Mar 7, 2021·International Journal of Biological Macromolecules·Sunisa YoodeeVisith Thongboonkerd
Aug 21, 2021·The Kaohsiung Journal of Medical Sciences·Jian ZhangNian Yang
Nov 25, 2021·Journal of Cancer Research and Clinical Oncology·Takeo YamamotoYoshinao Oda
Dec 24, 2021·PLoS Genetics·Jake J ReskeRonald L Chandler

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Methods Mentioned

BETA
exome sequencing
PCR
Immunoprecipitation
Assay
Protein Assay
X-ray
transfection
gene knockdown
xenograft

Software Mentioned

SPSS
SDS

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