Loss of ARID1A expression is associated with poor prognosis in patients with stage I/II clear cell carcinoma of the ovary

International Journal of Clinical Oncology
Hiroaki ItamochiTasuku Harada

Abstract

Recent studies have shown that somatic mutations in the AT-rich interactive domain 1A (SWI-like) gene (ARID1A) are the most common genetic changes in clear cell carcinoma of the ovary (CCC). A gene mutation of ARID1A was found in approximately half of CCC cases, and led to absence of the encoded protein and inactivation of the putative tumor suppressor. Here, we investigated whether ARID1A could be a prognostic biomarker for this disease. We analyzed the protein expression of ARID1A in CCC from 112 patients by immunohistochemical staining, and evaluated the association of these molecular parameters with clinical outcome. The loss of ARID1A expression was found in 39 % (44/112) of CCC, and was not associated with patient age, FIGO stage, and status of residual tumor. The 5-year survival rate for FIGO stage I or II patients with negative tumor expression of ARID1A was lower than those with positive tumor expression of ARID1A (74 % vs 91 %), but this difference was not observed in FIGO stage III or IV patients. Multivariable analysis revealed that ARID1A expression was an independent prognostic factor in FIGO stage I or II CCC patients. ARID1A may be a biomarker that is predictive of the outcome of FIGO stage I and II CCC.

References

Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
May 12, 2007·Genes, Chromosomes & Cancer·Jianmin HuangSheng Xiao
Apr 2, 2008·Cancer Science·Hiroaki ItamochiNaoki Terakawa
Apr 8, 2009·The American Journal of Pathology·Kuan-Ting KuoIe-Ming Shih
Jan 30, 2010·Nature·Lena Ho, Gerald R Crabtree
Oct 15, 2010·The New England Journal of Medicine·Kimberly C WiegandDavid G Huntsman
Mar 18, 2011·The American Journal of Surgical Pathology·Bin GuanIe-Ming Shih
Jan 1, 2010·International Journal of Molecular Sciences·Daichi MaedaIe-Ming Shih
Jun 10, 2011·Nature Reviews. Cancer·Boris G Wilson, Charles W M Roberts
Nov 22, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Atsuko KatagiriKohji Miyazaki
Nov 29, 2011·Virchows Archiv : an International Journal of Pathology·Sohei YamamotoOsamu Matsubara
Dec 24, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·William J LoweryAndrew Berchuck
Feb 4, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eleftherios P SamartzisPatrick Imesch
Sep 15, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ayse AyhanIe-Ming Shih
Feb 19, 2013·The American Journal of Pathology·Zsuzsanna LichnerGeorge M Yousef
May 25, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tjalling BosseVincent T H B M Smit
Jun 15, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Melissa K McConechyDavid G Huntsman
Aug 22, 2013·Journal of the Chinese Medical Association : JCMA·Chiung-Ru LaiAnna Fen-Yau Li
Oct 1, 2013·The American Journal of Surgical Pathology·Tsui-Lien MaoIe-Ming Shih
Dec 18, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hsien-Neng HuangKuan-Ting Kuo
Jan 25, 2014·Journal of Gynecologic Oncology·Yoshihito YokoyamaHideki Mizunuma
Jul 1, 2014·Oncotarget·Eleftherios P SamartzisPatrick Imesch
Oct 25, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Aikou OkamotoAmit Oza

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Citations

Jun 16, 2015·Genes·Gernot Längst, Laura Manelyte
Jan 19, 2018·The Journal of Pathology·Jennifer X JiDavid G Huntsman
Nov 23, 2016·Yonsei Medical Journal·Jae Yoon ChoiNam Hoon Cho
Oct 27, 2015·Journal of Pathology and Translational Medicine·Inju Cho, Sung-Chul Lim
Jan 25, 2020·Annual Review of Pathology·Yemin WangDavid G Huntsman
Nov 3, 2017·Gynecologic Oncology Research and Practice·Jill K Alldredge, Ramez N Eskander
Nov 18, 2015·Oncology Reports·Takashi TakedaDaisuke Aoki
Jan 21, 2017·Experimental and Therapeutic Medicine·Changshuai LyuJinghe Lang
Apr 11, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masataka TakenakaUNKNOWN Australian Ovarian Cancer Study Group
Sep 9, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jennifer A BennettEsther Oliva
Mar 15, 2021·Journal of Cancer Research and Clinical Oncology·Corey M GillRaj K Shrivastava
Jul 5, 2017·Gynecologic Oncology·Ayako KawabataAikou Okamoto

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