Loss of B-cell lymphoma 2 immunohistochemical expression in endometrial hyperplasia: A specific marker of precancer and novel indication for treatment: A systematic review and meta-analysis

Acta Obstetricia Et Gynecologica Scandinavica
Antonio TravaglinoFulvio Zullo

Abstract

Endometrial hyperplasia is differentiated into benign or premalignant. Two histological classifications are used for this purpose: World Health Organization (WHO) classification, based on cytological atypia, disregarding glandular complexity, and endometrial intraepithelial neoplasia (EIN) classification, based on several different parameters. B-cell lymphoma 2 (Bcl-2) loss has been studied as immunohistochemical marker with the aim of improving the differential diagnosis between benign and premalignant hyperplasia. We aimed to evaluate: (A) Bcl-2 loss as marker of endometrial precancer, by assessing it in proliferative endometrium, benign hyperplasia, premalignant hyperplasia, and endometrial cancer; (B) the diagnostic accuracy of Bcl-2 in the differential diagnosis between benign and premalignant endometrial hyperplasia; (c) how the results change according to the histological classification and the thresholds of Bcl-2 expression used. Electronic databases were searched from their inception to March 2018. All studies assessing Bcl-2 immunohistochemistry in endometrial specimens were included. In total, 20 observational studies assessing 1,278 specimens were included. Bcl-2 loss rates were not significantly different between p...Continue Reading

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Citations

Dec 5, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo
Oct 23, 2018·Histopathology·Antonio TravaglinoFulvio Zullo
Feb 5, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo
Feb 26, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio TravaglinoFulvio Zullo
Feb 26, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio TravaglinoFulvio Zullo
Feb 5, 2019·American Journal of Clinical Pathology·Antonio TravaglinoFulvio Zullo
Jun 6, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antonio RaffoneFulvio Zullo
Aug 14, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio TravaglinoFulvio Zullo
Aug 25, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneMaurizio Guida
Aug 25, 2019·Pathology Oncology Research : POR·Antonio RaffoneGian Franco Zannoni
Sep 23, 2019·Archives of Gynecology and Obstetrics·Ruggero LionettiFrancesco Corcione
Aug 23, 2019·American Journal of Clinical Pathology·Antonio TravaglinoFulvio Zullo
Sep 19, 2019·Archives of Gynecology and Obstetrics·Antonio TravaglinoFulvio Zullo
Dec 20, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Antonio TravaglinoFulvio Zullo
Jun 27, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio RaffoneFulvio Zullo
Mar 28, 2019·Archives of Gynecology and Obstetrics·Antonio RaffoneFulvio Zullo
Jun 17, 2019·Pathology Oncology Research : POR·Antonio RaffoneFulvio Zullo
Sep 2, 2019·Gynecologic Oncology·Antonio RaffoneFulvio Zullo
Jan 15, 2020·Gynecologic Oncology·Antonio RaffoneFulvio Zullo
Feb 23, 2021·Pathology, Research and Practice·Antonio TravaglinoMassimo Mascolo

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