Abstract
Endometrial hyperplasia is differentiated into benign or premalignant. Two histological classifications are used for this purpose: World Health Organization (WHO) classification, based on cytological atypia, disregarding glandular complexity, and endometrial intraepithelial neoplasia (EIN) classification, based on several different parameters. B-cell lymphoma 2 (Bcl-2) loss has been studied as immunohistochemical marker with the aim of improving the differential diagnosis between benign and premalignant hyperplasia. We aimed to evaluate: (A) Bcl-2 loss as marker of endometrial precancer, by assessing it in proliferative endometrium, benign hyperplasia, premalignant hyperplasia, and endometrial cancer; (B) the diagnostic accuracy of Bcl-2 in the differential diagnosis between benign and premalignant endometrial hyperplasia; (c) how the results change according to the histological classification and the thresholds of Bcl-2 expression used. Electronic databases were searched from their inception to March 2018. All studies assessing Bcl-2 immunohistochemistry in endometrial specimens were included. In total, 20 observational studies assessing 1,278 specimens were included. Bcl-2 loss rates were not significantly different between p...Continue Reading
References
Jul 15, 1985·Cancer·R J KurmanH J Norris
Nov 1, 1995·The Journal of Pathology·W K ChanA M Hanby
Dec 1, 1996·Gynecologic Oncology·T H NiemannL Vaccarello
Mar 1, 1997·Human Pathology·T NakamuraS Nariya
Oct 22, 1998·Human Pathology·O B IoffeC B Drachenberg
Feb 3, 1999·Cancer Letters·R MiturskiJ Jakowicki
Feb 24, 2000·Gynecologic Oncology·G L Mutter
Apr 27, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·H M MorsiN Lang
Aug 15, 2000·Molecular and Cellular Endocrinology·T E VaskivuoJ S Tapanainen
Sep 28, 2001·Human Reproduction·K KokawaM Yamoto
Oct 18, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·G PeiróU Löhrs
Jul 9, 2002·Pathology International·Leyla CinelReyhan Eğilmez
Sep 10, 2002·Gynecologic Oncology·Noriaki SakuragiSeiichiro Fujimoto
Oct 16, 2003·Maturitas·Hugo MaiaElsimar Coutinho
Dec 30, 2004·Journal of Clinical Pathology·J P A Baak, G L Mutter
Apr 28, 2005·Cancer·Jan P BaakRené H Verheijen
Jul 29, 2006·Journal of Clinical Pathology·W G McCluggage
Feb 24, 2007·Pathology, Research and Practice·Nilgun KapucuogluMetin Ciriş
Jul 25, 2009·Pathology International·Osamu NunobikiKennichi Kakudo
Feb 18, 2011·American Journal of Obstetrics and Gynecology·Anita SteinbakkJan P Baak
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Jun 26, 2012·American Journal of Obstetrics and Gynecology·Kristen UpsonRochelle L Garcia
Sep 29, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A SotiriadisW P Martins
Mar 15, 2016·Pathology, Research and Practice·Kemal Kürşat BozkurtNilgün Kapucuoğlu
Sep 16, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Tomasz BanasJoanna Cielecka-Kuszyk
Dec 23, 2017·Pathology Oncology Research : POR·Levent TrabzonluAydin Corakci
Jan 19, 2018·The Journal of Pathology·Jessica McAlpineTjalling Bosse
Citations
Dec 5, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo
Dec 5, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo
Oct 23, 2018·Histopathology·Antonio TravaglinoFulvio Zullo
Feb 5, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo
Feb 28, 2019·Archives of Gynecology and Obstetrics·Antonio RaffoneFulvio Zullo
Feb 23, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Antonio TravaglinoFulvio Zullo
Feb 26, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio TravaglinoFulvio Zullo
Feb 26, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio TravaglinoFulvio Zullo
Feb 20, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneFulvio Zullo
Feb 5, 2019·American Journal of Clinical Pathology·Antonio TravaglinoFulvio Zullo
Jun 6, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antonio RaffoneFulvio Zullo
Aug 14, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio TravaglinoFulvio Zullo
Aug 25, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Antonio RaffoneMaurizio Guida
Aug 25, 2019·Pathology Oncology Research : POR·Antonio RaffoneGian Franco Zannoni
Sep 23, 2019·Archives of Gynecology and Obstetrics·Ruggero LionettiFrancesco Corcione
Aug 23, 2019·American Journal of Clinical Pathology·Antonio TravaglinoFulvio Zullo
Sep 19, 2019·Archives of Gynecology and Obstetrics·Antonio TravaglinoFulvio Zullo
Dec 20, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Antonio TravaglinoFulvio Zullo
Jun 27, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Antonio RaffoneFulvio Zullo
Mar 28, 2019·Archives of Gynecology and Obstetrics·Antonio RaffoneFulvio Zullo
Jun 17, 2019·Pathology Oncology Research : POR·Antonio RaffoneFulvio Zullo
Aug 18, 2020·Journal of Adolescent and Young Adult Oncology·Antonio RaffoneFulvio Zullo
Sep 2, 2019·Gynecologic Oncology·Antonio RaffoneFulvio Zullo
Jan 15, 2020·Gynecologic Oncology·Antonio RaffoneFulvio Zullo
Feb 23, 2021·Pathology, Research and Practice·Antonio TravaglinoMassimo Mascolo