Loss of BAP1 Expression Occurs Frequently in Intrahepatic Cholangiocarcinoma

Medicine
Juliana AndriciAnthony J Gill

Abstract

BRCA1-associated protein 1 (BAP1) is a deubiquitinating enzyme that functions as a tumor suppressor gene. Double hit BAP1 inactivation has been reported in a range of tumor types, including intrahepatic cholangiocarcinoma (ICC), sometimes in association with germline mutation.We performed immunohistochemistry for BAP1 on a well-characterized cohort of 211 ICC patients undergoing surgical resection with curative intent at 3 institutions based in 3 different countries. The median age at diagnosis was 65 years (range, 36.5-86) and 108 (51%) were men. Negative staining for BAP1 (defined as completely absent nuclear staining in the presence of positive internal controls in nonneoplastic cells) occurred in 55 ICCs (26%). BAP1 loss predicted a strong trend toward improved median survival of 40.80 months (95% CI, 28.14-53.46) versus 24.87 months (95% CI, 18.73-31.01), P = 0.059). In a multivariate model including age, sex, BAP1 status, tumor stage, tumor grade, lymphovascular invasion, and tumor size, female sex was associated with improved survival (hazard ratio [HR] 0.54; 95% CI, 0.34-0.85), while advanced tumor stage and lymphovascular invasion (HR 1.89; 95% CI, 1.09-3.28) correlated with decreased survival. In a multivariate analys...Continue Reading

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Citations

Apr 27, 2016·Pathology·Juliana AndriciAnthony J Gill
Mar 25, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Masayuki AkitaYoh Zen
Feb 21, 2018·Future Oncology·Thomas T DeLeonMitesh J Borad
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Apr 1, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jeanie ChuiAnthony J Gill
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Jul 10, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eunhyang ParkNam Hoon Cho
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Sep 19, 2020·Oral Diseases·Lucas Alves da Mota SantanaSílvia Ferreira de Sousa
Jul 15, 2017·Pathology·Jeanie ChuiAnthony J Gill
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Nov 23, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keisaku SatoGianfranco Alpini
Oct 2, 2021·The Journal of Biological Chemistry·Yuki IshiiSam M Janes

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS Statistics

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