PMID: 15381903Sep 24, 2004Paper

Loss of beta-catenin is associated with poor survival in ovarian carcinomas

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
C Faleiro-RodriguesC S Lopes

Abstract

The catenins (alpha-, beta- and gamma-) are cytoplasmic proteins that bind to the conserved tail of the epithelial cadherin molecule. The function of epithelial cadherin at the adherens junctions is dependent on the catenins for efficient cell-to-cell adhesion. Loss of catenin expression has been reported in several human cancers and associated with poor tumor differentiation, advanced tumor stage, and poor patient survival. In this study, we investigated the clinical relevance of alpha-, beta-, and gamma-catenin immunoexpression in 104 cases of primary ovarian carcinoma with respect to clinicopathological features and as predictors of disease recurrence and prognosis. The clinicopathological parameters studied were International Federation of Gynaecology and Obstetrics (FIGO) stage, histological type, tumor differentiation, peritoneal metastases, residual postoperative tumor, integrity of the tumor's serosal surface, peritoneal cytology, and lymphatic/vascular invasion. Negative immunoreactivity of alpha-catenin, beta-catenin, and gamma-catenin was observed in 22 (21%), 15 (14%) and 23 (22%) cases, respectively. Immunoreactivity of alpha-catenin and gamma-catenin did not correlate with any of the clinicopathological parameters...Continue Reading

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Citations

Oct 13, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daniel G RosenJinsong Liu
Jun 23, 2009·The American Journal of Surgical Pathology·Julia Turbiner GeyerEsther Oliva
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