Loss of bone strength in HLA-B27 transgenic rats is characterized by a high bone turnover and is mainly osteoclast-driven

Bone
Martina RaunerLorenz C Hofbauer

Abstract

Although osteopenia is frequent in spondyloarthritis (SpA), the underlying cellular mechanisms and association with other symptoms are poorly understood. This study aimed to characterize bone loss during disease progression, determine cellular alterations, and assess the contribution of inflammatory bowel disease (IBD) to bone loss in HLA-B27 transgenic rats. Bones of 2-, 6-, and 12-month-old non-transgenic, disease-free HLA-B7 and disease-associated HLA-B27 transgenic rats were examined using peripheral quantitative computed tomography, μCT, and nanoindentation. Cellular characteristics were determined by histomorphometry and ex vivo cultures. The impact of IBD was determined using [21-3 x 283-2]F1 rats, which develop arthritis and spondylitis, but not IBD. HLA-B27 transgenic rats continuously lost bone mass with increasing age and had impaired bone material properties, leading to a 3-fold decrease in bone strength at 12 months of age. Bone turnover was increased in HLA-B27 transgenic rats, as evidenced by a 3-fold increase in bone formation and a 6-fold increase in bone resorption parameters. Enhanced osteoclastic markers were associated with a larger number of precursors in the bone marrow and a stronger osteoclastogenic res...Continue Reading

References

Aug 18, 1999·Immunological Reviews·J D TaurogR E Hammer
May 3, 2000·Clinical Rheumatology·N Yilmaz, J Ozaslan
Jul 6, 2000·The Journal of Clinical Investigation·M T FiorilloR Sorrentino
Oct 7, 2000·Journal of Periodontology·D N Tatakis, P Guglielmoni
Jul 9, 2003·Arthritis and Rheumatism·Georg SchettJosef S Smolen
Oct 14, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·P BormanE E Bostan
Apr 24, 2007·Lancet·Jürgen Braun, Joachim Sieper
Jan 27, 2009·Nature Genetics·Rajan P NairUNKNOWN Collaborative Association Study of Psoriasis
Feb 7, 2009·Annals of the Rheumatic Diseases·K PolzerJ Zwerina
Apr 3, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicole C WalshEllen M Gravallese
Jun 10, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mary L BouxseinRalph Müller
Sep 23, 2010·Annals of the Rheumatic Diseases·Gisela Ruiz HeilandJochen Zwerina
Dec 25, 2010·International Journal of Dermatology·Enas A S AttiaAbeer A Saad
May 10, 2012·Arthritis Research & Therapy·Eva KlingbergHelena Forsblad-d'Elia
Oct 23, 2012·Rheumatic Diseases Clinics of North America·Rik J U Lories, Georg Schett
Dec 1, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David W DempsterA Michael Parfitt
Jan 10, 2013·PloS One·Kresten Krarup KellerEllen-Margrethe Hauge
Jun 12, 2013·Nature Genetics·UNKNOWN International Genetics of Ankylosing Spondylitis Consortium (IGAS)Matthew A Brown

❮ Previous
Next ❯

Citations

May 16, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kristofor BogoevskiVaida Glatt
Nov 27, 2019·International Journal of Molecular Sciences·Giovanni AdamiDavide Gatti
Dec 31, 2019·Experimental and Therapeutic Medicine·Chenghai Wang, Weifeng Li
Dec 19, 2019·International Journal of Molecular Sciences·Ke KeYousef Abu-Amer
Jun 22, 2021·Frontiers in Immunology·Giulia FuresiMartina Rauner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.