Loss of calponin h1 in renal angiomyolipoma correlates with aggressive clinical behavior

Urology
A H M Manjurul IslamOsamu Nishizawa

Abstract

To investigate whether any immunohistochemical differences exist between two types of renal angiomyolipomas (AMLs). Renal AMLs are generally considered to be benign in nature. However, a few of these tumors have been reported to involve other organs. Tissue specimens from 3 cases of clinically aggressive and 9 cases of clinically indolent renal AMLs were examined histologically and immunohistochemically using antibodies against calponin h1 and alpha-smooth muscle actin. Immunostaining was evaluated semiqualitatively as no staining to strong staining. The tumor cells in the myomatous component of the aggressive type did not show any reaction to the antibody to calponin h1 protein, but they showed strong immunoreactions with the antibody to the alpha-smooth muscle actin antigen. All cases of the nonaggressive AMLs demonstrated strong immunoreactions with both antibodies used. Our initial results in a small series of cases suggest a potential molecular difference between the aggressive and nonaggressive type of AMLs. Loss of calponin h1 from the tumor cells of the aggressive type might be related to their pathologically invasive features, and this aggressive type might be categorized into an intermediate type between the benign an...Continue Reading

References

Nov 1, 1991·The American Journal of Surgical Pathology·J A FerryR H Young
Nov 12, 1990·FEBS Letters·M GimonaJ V Small
Nov 26, 1986·Biochemical and Biophysical Research Communications·K TakahashiT Kokubu
Oct 1, 1993·Clinical Radiology·D B Reiff, J Dow
Mar 1, 1996·Histopathology·K T MaiJ P Collins
Aug 1, 1996·Journal of Biochemistry·H MasudaK Takahashi
Jan 14, 1998·Urology·M R BernsteinA J Wein
May 24, 2001·Archives of Pathology & Laboratory Medicine·C H StoneR J Zarbo
Jan 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M TakeokaS Taniguchi
Jun 1, 1965·Cancer·E B PRICE, F K MOSTOFI

❮ Previous
Next ❯

Citations

Jun 4, 2013·Virchows Archiv : an International Journal of Pathology·Vikas MehtaMaria M Picken
Oct 24, 2008·Cell Biochemistry and Biophysics·Kai-Chun Wu, J-P Jin
Oct 10, 2009·Urology·Stephen C JohnsonW Bruce Shingleton
Nov 1, 2007·Proteomics. Clinical Applications·Joshua K McBeeRichard S Morrison
Jan 6, 2009·Journal of Cellular and Molecular Medicine·H R KimK G Morgan
Apr 30, 2011·Archives of Pathology & Laboratory Medicine·Ozgur Mete, Theodorus H van der Kwast

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.