Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer's disease mice

Neuroscience Letters
Fatima ZalloJosé J Rodríguez

Abstract

Neuronal degeneration associated with Alzheimer's disease (AD), is linked to impaired calcium homeostasis and to changes in calcium-binding proteins (CBPs). The AD-related modification of neuronal CBPs remains controversial. Here we analysed the presence and expression of calretinin (CR) and parvalbumin (PV) in the hippocampal CA1 neurones of 18 months old 3xTg-AD mice compared to non-Tg animals. We found a layer specific decrease in number of interneurones expressing CR and PV (by 33.7% and 52%, respectively). Expression of PV decreased (by 13.8%) in PV-positive neurones, whereas expression of CR did not change in CR positive cells. The loss of specific subpopulations of Ca2+-binding proteins expressing interneurones (CR and PV) together with the decrease of PV in the surviving cells may be linked to their vulnerability to AD pathology. Specific loss of inhibitory interneurones with age could contribute to overall increase in the network excitability associated with AD.

Citations

Sep 7, 2019·Brain Pathology·Elisabeth Sanchez-MejiasAntonia Gutierrez
Apr 11, 2019·Frontiers in Molecular Neuroscience·Cristina CatoniMarisa Brini
May 16, 2019·International Journal of Molecular Sciences·Giacomo Gattoni, Graziella Bernocchi
May 6, 2019·International Journal of Molecular Sciences·Richard FairlessRicarda Diem
Oct 12, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Polina A VishnyakovaPetr M Masliukov
Nov 5, 2020·International Journal of Molecular Sciences·Oliver Wirths, Silvia Zampar
Jan 16, 2021·International Journal of Molecular Sciences·Hyeon Jeong SeoByeong C Kim
Apr 16, 2021·Neural Plasticity·Wojciech KozubskiJolanta Dorszewska
Jun 6, 2021·Neuroscience Bulletin·Yang Ying, Jian-Zhi Wang
Jul 6, 2021·Frontiers in Psychiatry·Lailun NaharHyung W Nam
Jul 17, 2021·Neuroscience Letters·Connor M Wander, Juan Song

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