Loss of CDX2 gene expression is associated with DNA repair proteins and is a crucial member of the Wnt signaling pathway in liver metastasis of colorectal cancer

Oncology Letters
Csaba TóthLászló Tiszlavicz

Abstract

Caudal type homeobox 2 (CDX2) has been well-established as a diagnostic marker for colorectal cancer (CRC); however, less is known about its regulation, particularly its potential interactions with the DNA repair proteins, adenomatous polyposis coli (APC) and β-catenin, in a non-transcriptional manner. In the present study, the protein expression of CDX2 was analyzed, depending on the expression of the DNA repair proteins, mismatch repair (MMR), O6-methylguanine DNA methyltransferase (MGMT) and excision repair cross-complementing 1 (ERCC1), and its importance in Wnt signaling was also determined. A total of 101 liver metastases were punched into tissue microarray (TMA) blocks and serial sections were cut for immunohistochemistry. For each protein, an immunoreactive score was generated according to literature data and the scores were fitted to TMA. Subsequently, statistical analysis was performed to compare the levels of expression with each other and with clinical data. CDX2 loss of expression was observed in 38.5% of the CRC liver metastasis cases. A statistically significant association between CDX2 and each of the investigated MMRs was observed: MutL Homolog 1 (P<0.01), MutS protein Homolog (MSH) 2 (P<0.01), MSH6 (P<0.01), a...Continue Reading

References

Jan 5, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·R L CampD L Rimm
Dec 6, 2001·The American Journal of Pathology·J TorhorstG Sauter
Mar 20, 2002·Nature Reviews. Cancer·R FoddeH Clevers
Sep 12, 2002·EMBO Reports·Beric R Henderson, Francois Fagotto
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Sep 22, 2005·Journal of the National Cancer Institute·Lanlan ShenJean-Pierre J Issa
Apr 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Annamaria RuzzoMauro Magnani
Jul 25, 2009·International Journal of Cancer. Journal International Du Cancer·Hua-Yun ChenZhong-Ping Chen
Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nicholas J HawkinsMegan P Hitchins
Nov 26, 2009·Advances in Experimental Medicine and Biology·Kristi L Neufeld
Nov 1, 2011·World Journal of Gastroenterology : WJG·Evangelos P MisiakosGregory Kouraklis
Dec 23, 2011·Nucleic Acids Research·Benjamin RenoufClaire Domon-Dell
Apr 13, 2012·Genome Integrity·Alexander FacistaCarol Bernstein
Jun 28, 2012·World Journal of Gastrointestinal Pathophysiology·Samar HassenParimal Chowdhury
Feb 9, 2013·Carcinogenesis·Anders Krüger OlsenJesper Thorvald Troelsen
May 25, 2013·Pathology, Research and Practice·Renê GerhardFernando Schmitt
Jun 13, 2013·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Michela Garofalo, Carlo M Croce
Mar 8, 2014·Scientific Reports·David Hersi SmithSussie Steen Jensen
Sep 23, 2014·BioMed Research International·Xia LiYashuang Zhao
Oct 17, 2014·The Journal of Biological Chemistry·Alexa HryniukDavid Lohnes
Dec 18, 2014·World Journal of Clinical Cases·Alessandro InnoFilippo Pietrantonio
Jun 3, 2015·International Journal of Oncology·Giulio CabriniRoberto Gambari
May 10, 2017·Journal of Hematology & Oncology·Sachin Gopalkrishna PaiFrancis Joseph Giles

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May 15, 2021·OncoTargets and Therapy·Wubin ZhengWeiwei Tang

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