Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity

Frontiers in Cell and Developmental Biology
Xiaowei ZhouAijun Zhang

Abstract

Impaired endometrial receptivity is one of the major causes of recurrent implantation failure (RIF), although the underlying molecular mechanism has not been fully elucidated. In the present study, we demonstrated that chromodomain Y like (CDYL) was highly expressed in the endometrium at mid-secretory phase during the normal menstrual cycles. However, the expression of CDYL was downregulated in the endometrial tissues obtained from women with RIF, consistently with the protein level of LIF, which is a marker of endometrial receptivity. In CDYL-knockdown human endometrial Ishikawa cells, we identified 1738 differentially expressed genes (DEGs). Importantly, the catenin beta 1 (CTNNB1) expression was dramatically reduced responding to the CDYL inhibition, both in Ishikawa cells as well as the primary endometrial epithelial and stromal cells. In addition, the expression of CTNNB1was decreased in the endometrium from RIF patients as well. These results suggested that the expression of CTNNB1 was regulated by CDYL in endometrium. The cell migration was impaired by CDYL-knockdown in Ishikawa cells and primary endometrial stromal cells (ESCs), which could be rescued by CDYL or CTNNB1 overexpression. Collectively, our findings indicate...Continue Reading

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Citations

Apr 3, 2021·Scientific Reports·Hwa Seon KooYoun-Jung Kang
Feb 24, 2021·The Journal of Clinical Endocrinology and Metabolism·Junyu ZhaiYanzhi Du
May 19, 2021·Human Fertility : Journal of the British Fertility Society·Chibuzor Ifenatuoha, Babatunde Okewale

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Datasets Mentioned

BETA
GSE103465
GSE141239

Methods Mentioned

BETA
RNA Extraction
PCR
immunoprecipitation assay
protein assay
electrophoresis
biopsy
transfection
RNA-seq
biopsies

Software Mentioned

String
Cytospace
Cytoscape
Image J
SPSS
TopHat

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