PMID: 7545031May 1, 1995Paper

Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells

Molecular Biology of the Cell
M KatoM Bernfield

Abstract

Simple epithelial cells are polygonal in shape, polarized in an apical-basal orientation, and organized into closely adherent sheets, characteristics that result from a variety of cellular specializations and adhesive proteins. These characteristics are lost when the epithelia transform during embryogenesis into mesenchymal cells or after neoplasia into invasive carcinoma cells. Of the syndecan family of transmembrane heparan sulfate proteoglycans, simple epithelia produce predominantly syndecan-1, which is found at basolateral surfaces and within adhesive junctions. To elucidate the function of this syndecan-1, normal murine mammary gland epithelia were made deficient in syndecan-1 by transfection with an expression vector containing the syndecan-1 cDNA in the antisense configuration. Several independently derived clones of stable transfectants contained the antisense cDNA in their genome and expressed the antisense transcript. These grew either as epithelial islands of closely adherent polygonal cells, identical to both the parental cells and the vector-only control transfectants, or as individual elongated fusiform cells that invaded and migrated within collagen gels, like mesenchymal cells, but were anchorage-independent fo...Continue Reading

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G David, M R Bernfield
Jan 1, 1978·Cell·R O Hynes, A T Destree
Dec 1, 1978·Cell Differentiation·P EkblomL Saxén
Jan 1, 1992·Annual Review of Cell Biology·M BernfieldE J Lose
Mar 1, 1990·The Journal of Cell Biology·H LarjavaK M Yamada
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H M WenzG M Ringold
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S LeppäM Jalkanen
Oct 1, 1991·Genomics·H F OettingerM Bernfield
Jan 1, 1991·Annals of the New York Academy of Sciences·M Bernfield, K C Hooper
Aug 1, 1991·The Journal of Cell Biology·K EleniusM Jalkanen
Jun 1, 1990·Developmental Biology·J L PlattT R Oegema
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M C KieferP J Barr
Nov 1, 1990·The Journal of Cell Biology·K M WeidnerW Birchmeier
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M OzawaR Kemler
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P GunningL Kedes
Feb 1, 1989·Developmental Biology·J E Fitchett, E D Hay
Apr 1, 1989·The Journal of Cell Biology·S SaundersM Bernfield
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E GherardiR Furlong
Jul 1, 1989·The Journal of Cell Biology·R O HynesG H Yee
Oct 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K HayashiM Bernfield
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H G HallM J Bissell
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·R L GalloM Bernfield
Jan 1, 1993·Journal of Cell Science. Supplement·B M Gumbiner, P D McCrea
Jan 1, 1993·Journal of Cell Science. Supplement·W BirchmeierJ Behrens

❮ Previous
Next ❯

Citations

Sep 27, 1996·International Journal of Cancer. Journal International Du Cancer·C J CarsbergP L Stern
Jun 20, 1997·International Journal of Cancer. Journal International Du Cancer·K NackaertsG David
Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·A MatsumotoY Kohgo
Jun 15, 1996·Journal of Cellular Biochemistry·J R Couchman, A Woods
Jul 15, 2009·Cell and Tissue Research·Xiaojie XianJohn R Couchman
Jun 5, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Brandon J BurbachAlan C Rapraeger
Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Atsuko Yoneda, John R Couchman
Jan 9, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·A WoodsJ R Couchman
Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A SebestyénL Kopper
Mar 15, 2000·The International Journal of Biochemistry & Cell Biology·S TumovaJ R Couchman
Aug 3, 2005·Nature Reviews. Cancer·Mark M Fuster, Jeffrey D Esko
Oct 24, 2012·Nature Reviews. Rheumatology·Thomas Pap, Jessica Bertrand
Mar 2, 1999·British Journal of Haematology·G P KaushalT Kelly
Oct 30, 2008·The Journal of Biological Chemistry·Kazutaka HayashidaPyong Woo Park
Mar 1, 1996·The Journal of Cell Biology·C S Lebakken, A C Rapraeger
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C HagiosM J Bissell
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Patricia Murray, David Edgar
Jun 29, 2000·Annual Review of Biochemistry·M BernfieldM Zako
Jul 29, 2011·American Journal of Physiology. Cell Physiology·Feng-Pai ChouChen-Yong Lin
Dec 22, 2012·American Journal of Respiratory Cell and Molecular Biology·Sina A GharibPeter Chen
Feb 9, 2006·BMC Microbiology·Taissia G PopovaSerguei G Popov
Jan 9, 2004·Reproductive Biology and Endocrinology : RB&E·DeannaLee M Beauvais, Alan C Rapraeger
Aug 18, 2012·Journal of Cell Science·William A AltemeierPeter Chen
Aug 18, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anna S Eriksson, Dorothe Spillmann
Apr 9, 2008·World Journal of Gastroenterology : WJG·Yong-Quan ChuZhong-Sheng Zhao
Jan 26, 2011·European Journal of Histochemistry : EJH·T LorenziD Marzioni
Aug 29, 2013·BioMed Research International·Angélica M GomesMauro S G Pavão
Jul 12, 2013·BioMed Research International·Vassiliki T LabropoulouAchilleas D Theocharis
Apr 26, 2014·Journal of Cancer Research and Therapeutics·B LakkamS Ramasahayam
Aug 21, 2014·BioMed Research International·Dragana NikitovicGeorge N Tzanakakis
Oct 4, 2011·Cellular and Molecular Life Sciences : CMLS·Elena GarusiRoberto Perris
Dec 7, 2007·The Journal of Cell Biology·Leontine L Galante, Jean E Schwarzbauer
May 28, 2014·Thrombosis Research·Mattias Belting
Nov 7, 1999·Journal of Cutaneous Pathology·I B Bayer-GarnerB R Smoller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.