PMID: 7547636Aug 1, 1995Paper

Loss of chromosome 17 loci in prostate cancer detected by polymerase chain reaction quantitation of allelic markers

Genes, Chromosomes & Cancer
A R BrothmanR A Stephenson

Abstract

Using a polymerase chain reaction/microsatellite marker system, we demonstrated that 6 of 22 (27%) clinical stage B (early) primary prostate tumors showed loss of heterozygosity at one or more of five loci on chromosome 17. The sensitivity of this study was increased by use of a PhosphorImager and statistical analysis of replicate tumor-normal DNA pairs. Two patients showed tumor-specific interstitial loss at a locus in close proximity to the familial breast cancer gene BRCA1. These findings suggest that genes on the proximal long arm of chromosome 17 play a pivotal role in the early development of at least a subset of prostatic tumors.

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Citations

Dec 16, 1997·The Prostate·M A ChekmarevaC W Rinker-Schaeffer
Feb 13, 1999·International Journal of Cancer. Journal International Du Cancer·T UchidaK Koshiba
Sep 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N D James, J Glaholm
May 1, 1997·Cancer Genetics and Cytogenetics·A R Brothman
Jun 3, 2005·Clinical Medicine & Research·Kai Qi ZhangJames K Burmester
Aug 6, 1999·Cancer Investigation·R S VermaC J Godec
Jun 19, 2001·Cancer Investigation·E M RosenI D Goldberg
Feb 1, 1996·The Journal of Urology·B J WilliamsA R Brothman
Mar 5, 2004·Prostate Cancer and Prostatic Diseases·M K Karayi, A F Markham
Apr 2, 2003·Development·Kyriakos D Economides, Mario R Capecchi

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