PMID: 9557770Apr 29, 1998Paper

Loss of cochlear nucleus neurons following aminoglycoside antibiotics or cochlear removal

The Annals of Otology, Rhinology, and Laryngology
D R MooreS J O'Leary

Abstract

This study compared the effects of aminoglycoside ototoxicity and surgical ablation of the cochlea in infancy on the survival of neurons in the rat cochlear nucleus (CN). Ototoxicity was induced by a single, systemic dose of gentamicin sulfate and furosemide on postnatal day 6 (P6), P7, or P10, and assessed by the elevation of auditory brain stem response thresholds, as described in a companion paper. Unilateral cochlear removals were performed under Saffan anesthesia on P6, P9, and P12. Rats were painlessly sacrificed in adulthood, and the formalin-perfused brains and cochleas were embedded in wax, sectioned, and stained. Ototoxic treatment at P6 through P10 did not reduce neuron counts in the CN. Cochlear removal at P6 resulted in a 40% loss of CN neurons, but removal at P12 did not result in CN neuron loss. These data suggest that the critical period for the dependence of CN neurons on afferent input from the cochlea ends at the same time that susceptibility to aminoglycoside ototoxicity begins.

References

Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Jan 1, 1990·Journal of Neurobiology·E W RubelD Durham
Jul 5, 1988·Brain Research·A Claps, F Torrealba
May 22, 1989·The Journal of Comparative Neurology·G T Hashisaki, E W Rubel
Apr 1, 1988·Hearing Research·P A Leake, G T Hradek
Aug 8, 1994·The Journal of Comparative Neurology·D I Lurie, E W Rubel
Apr 3, 1998·The Annals of Otology, Rhinology, and Laryngology·S J O'Leary, D R Moore

❮ Previous
Next ❯

Citations

Apr 2, 1999·The European Journal of Neuroscience·F A Russell, D R Moore
Oct 12, 2000·The Journal of Comparative Neurology·S P MostafapourE W Rubel
Nov 19, 2014·Bulletin of Experimental Biology and Medicine·I N D'yakonovaA M Tikhomirov
Dec 21, 2002·The European Journal of Neuroscience·Carmen Vale, Dan H Sanes
Feb 22, 2003·Cell and Tissue Research·Janet L Fitzakerley, Laura Schweitzer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.