Loss of Concurrent Regulation of the Expression of BIF-1, BAX, and Beclin-1 in Primary and Metastatic Melanoma.

Biochemistry. Biokhimii︠a︡
Ž FrangežH-U Simon

Abstract

Melanoma is one of the most aggressive and drug-resistant cancers. Despite novel promising therapeutic strategies, the prognosis of metastatic melanoma patients remains poor and it is often associated with high relapse rates. Endophilin B1, also known as BIF-1, is a multifunctional protein involved in several biological processes such as autophagy and apoptosis. BIF-1 promotes apoptosis through binding to BAX and its translocation to the mitochondrial outer membrane. On the other hand, BIF-1 can interact with Beclin-1 through UVRAG to promote autophagy. Several reports suggest an ambiguous role of BIF-1 in cancer development and progression. For example, it has been demonstrated that the expression of BIF-1 is reduced in both primary and metastatic melanoma and that the reduction of BIF-1 expression is associated with reduced overall survival of melanoma patients. Here we show that the expression of Beclin-1 and active form of BAX are also reduced in the melanoma patients. However, while we observed strong positive correlations between the expression of BIF-1 and Beclin-1 as well as between BIF-1 and BAX in benign nevi, these correlations were lost in the primary and metastatic melanoma cells. These data indicate disruption in ...Continue Reading

References

Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Y T TaiS A Cannistra
Mar 19, 1999·Journal of Cutaneous Pathology·E SprecherR Friedman-Birnbaum
Oct 18, 2001·The Journal of Cell Biology·K FarsadP De Camilli
Dec 13, 2002·International Journal of Cancer. Journal International Du Cancer·Dilek GünerPeter T Daniel
Nov 26, 2003·The Journal of Clinical Investigation·Xueping QuBeth Levine
Sep 29, 2004·The Journal of Cell Biology·Mariusz KarbowskiRichard J Youle
Oct 18, 2005·Molecular and Cellular Biology·Yoshinori TakahashiHong-Gang Wang
Mar 11, 2006·The Journal of Investigative Dermatology·Lothar F FeckerJürgen Eberle
Sep 25, 2007·Nature Cell Biology·Yoshinori TakahashiHong-Gang Wang
Apr 22, 2008·Methods in Molecular Biology·Isei TanidaEiki Kominami
Oct 4, 2008·Cancer·Domenico CoppolaHong-Gang Wang
Aug 5, 2010·Nature Reviews. Molecular Cell Biology·Stephen W G Tait, Douglas R Green
Dec 25, 2010·Cell Biochemistry and Biophysics·Ole KjaerulffAnita Jung
May 4, 2011·Melanoma Research·Efthimios SivridisAlexandra Giatromanolaki
Jan 15, 2014·Apoptosis : an International Journal on Programmed Cell Death·Subhadip MukhopadhyaySujit Kumar Bhutia
Nov 8, 2014·The EMBO Journal·Franziska TodtFrank Edlich
Feb 7, 2017·Nature Reviews. Immunology·Shigekazu Nagata, Masato Tanaka
Sep 22, 2017·Autophagy·Li YuSharon A Tooze
Dec 6, 2017·Scientific Reports·Peter BankheadPeter W Hamilton
Jan 19, 2019·Nature Reviews. Molecular Cell Biology·Rumani SinghKristopher Sarosiek

❮ Previous
Next ❯

Citations

Aug 31, 2021·Frontiers in Oncology·Živa FrangežHans-Uwe Simon

❮ Previous
Next ❯

Methods Mentioned

BETA
lipidation

Software Mentioned

Image Pro Plus
QuPath
GraphPad
Prism

Related Concepts

Related Feeds

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.