Loss of Consciousness Is Related to White Matter Injury in Mild Traumatic Brain Injury

Journal of Neurotrauma
Elisabeth A WildeHarvey S Levin

Abstract

To study the relation of loss of consciousness (LOC) to white matter integrity after mild traumatic brain injury (mTBI), we acquired diffusion tensor imaging (DTI) at 3 Tesla in 79 participants with mTBI and normal computed tomography (age 18 to 50 years) whom we imaged after a mean post-injury interval of 25.9 h (standard deviation = 12.3) and at 3 months. For comparison, 64 participants with orthopedic injury (OI) underwent DTI at similar intervals. Quantitative tractography was used to measure fractional anisotropy (FA) and mean diffusivity (MD) in the left and right uncinate fasciculus (UF), left and right inferior frontal occipital fasciculus (IFOF), and the genu of the corpus callosum. Generalized estimating equation models assessed the association between LOC and both MD and FA across time after mTBI and compared their DTI metrics with the OI group. LOC was significantly related to MD in UF and IFOF (p values ranged from p < 0.0001 to 0.0270) and to FA in left UF (p = 0.0104) and right UF (p = 0.0404). Between-group differences in MD were significant for left UF, left and right IFOF, and the genu of the corpus callosum on initial DTI, but not at 3 months post-injury, and these differences were specific to the mTBI subgro...Continue Reading

References

Nov 1, 1979·The Journal of Nervous and Mental Disease·H S LevinR G Grossman
Jul 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·P C BlumbergsJ B North
Jul 13, 1974·Lancet·G Teasdale, B Jennett
Jan 1, 1982·Addictive Behaviors·H A Skinner
Apr 3, 1998·Journal of Clinical and Experimental Neuropsychology·K O Yeates, H G Taylor
Jun 25, 2003·Brain : a Journal of Neurology·Marco CataniDominic H Ffytche
Jan 26, 2005·The Journal of Head Trauma Rehabilitation·John T Povlishock, Douglas I Katz
May 17, 2005·Journal of the International Neuropsychological Society : JINS·Rodney D VanderploegHeather G Belanger
Feb 20, 2007·Journal of Substance Abuse Treatment·Errol YudkoAdriana Fouts
Jan 31, 2008·The Journal of International Medical Research·A KayaI T Benli
Jul 16, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Marco Catani, Michel Thiebaut de Schotten
Jan 6, 2010·The American Journal of Psychiatry·Richard A BryantDerrick Silove
Jul 9, 2010·The Journal of Head Trauma Rehabilitation·Sumit N Niogi, Pratik Mukherjee
Jul 12, 2011·Journal of Neurotrauma·Kevin D BrowneDouglas H Smith
Dec 6, 2012·The American Journal of Psychiatry·Ricardo E JorgeVincent A Magnotta
Dec 12, 2012·Annals of Neurology·Esther L YuhUNKNOWN TRACK-TBI Investigators
Jan 12, 2013·AJNR. American Journal of Neuroradiology·M B HulkowerM L Lipton
Nov 15, 2013·Journal of Neurotrauma·Khader M HasanPonnada A Narayana
Jan 24, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Juan Martino, Enrique Marco De Lucas
May 2, 2014·Journal of Neurotrauma·Andrew B DoddAndrew R Mayer
Jul 26, 2014·NeuroImage. Clinical·Cyrus EierudStephen M LaConte
Jan 23, 2015·NeuroImage. Clinical·Ponnada A NarayanaJames J McCarthy
Mar 25, 2015·Lancet Neurology·Harvey S Levin, Ramon R Diaz-Arrastia
May 15, 2015·Brain Imaging and Behavior·Katherine M HelmickSidney R Hinds
Jun 25, 2015·NeuroImage. Clinical·Jasmeet P HayesMieke Verfaellie
Sep 8, 2015·Journal of Psychiatric Research·Gabriela IlieMichael D Cusimano

❮ Previous
Next ❯

Citations

Dec 23, 2016·Journal of Neurotrauma·Claudia S RobertsonPaul R Swank
Feb 1, 2018·The Journal of Head Trauma Rehabilitation·Yelena G BodienUNKNOWN TRACK-TBI Investigators
May 24, 2019·Journal of Neurotrauma·Elisabeth A WildeHarvey Levin
Mar 17, 2020·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Tim WendeJürgen Meixensberger
Aug 15, 2018·Frontiers in Cellular Neuroscience·Jyoti A ChuckowreeTracey C Dickson
Mar 16, 2021·Neuropsychology Review·Hannah M LindseyTricia L Merkley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.